恶性肿瘤气虚痰瘀证患者内分泌激素及免疫功能状态分析-中医内科学专业论文.docxVIP

摘 要 恶性肿瘤气虚痰瘀证患者内分泌激素 及免疫功能状态分析 摘 要 目的：探讨恶性肿瘤气虚痰瘀证与免疫细胞及内分泌激素变化的相关性。方法： 对入选的 83 例恶性肿瘤患者经中医辨证分型，采用放射免疫计数法和流式细胞仪测 定患者的 ACTH、CORT、IL-1β、IL-6、TNF-α 和血清 CD3+、CD4+、CD8+及 NK 细 胞数。结果：1）在 83 例恶性肿瘤患者中气虚痰瘀证 41 例占 49.39％，非气虚痰瘀 证 42 例占 50.61％（气滞证 11 例占 13.25％、气逆证 8 例占 9.64％、血虚证 7 例占 8.43％、血热证 6 例占 7.23％、水停证 6 例占 7.23％、津液亏虚证 4 例占 4.81％）； 2）①气虚痰瘀证组和非气虚痰瘀证组 CD3+、CD4+、CD4+/CD8+、NK 均下降，CD8+ 升高，上述指标与对照组比较差异有统计学意义（P＜0.01 或 P＜0.05）；其中气虚 痰瘀证组 CD3+、CD4+与非气虚痰瘀证组比较，差异有统计学意义（P＜0.05）。②气 虚痰瘀证组和非气虚痰瘀证组 IL-1β和 IL-6 与对照组比较均降低（P＜0.01），但两 组之间无明显差异（P＞0.05）。③气虚痰瘀证组和非气虚痰瘀证组患者血清中的 TNF- α含量均有所降低（P＞0.05），无统计学意义。④气虚痰瘀证组和非气虚痰瘀证组 患者的 ACTH 含量升高（P＜0.01），CORT 含量升高（P＜0.05），有统计学意义， 但两组之间无明显差异，无统计学意义（P＞0.05）。结论：1）气虚痰瘀证在恶性肿 瘤中医辨证分型中占有较大比例，说明气虚痰瘀证是恶性肿瘤重要证型；2）恶性肿 瘤气虚痰瘀证和非气虚痰瘀证都存在免疫细胞及内分泌激素方面的改变，尤以气虚 、 + 痰瘀证更加突出，主要以 CD3+、CD4+ CD8 、NK、IL-1β、ACTH 等的改变为主。 关键词：恶性肿瘤；气虚痰瘀证；免疫；内分泌激素 新疆医科大学医学硕士学位论文 Study on the Relationship Between Qi asthenia phlegm-stasis syndrome of the malignant tumor and Immunity Cell and Hormone secretion Abstract Objective：To analyse the Relationship Between Qi asthenia phlegm-stasis syndrome of the malignant tumor patients and Immunity Cell and Hormone secretion. Method：The flow cytometry technology and radio-immune technology were utilized to detect patients serum level of CD3+、CD4+、CD8+ 、NK cell、 IL-1β、IL-6、ACTH、CORT、TNF-α of 41 cases of malignant tumor with Qi asthenia and phlegm-stasis syndrome and 42 cases of malignant tumor with non- Qi asthenia and phlegm-stasis syndrome. Result：1) according to Traditional Chinese medicine dialectics type, the Qi asthenia and phlegm-stasis syndrome had 49.39%, the non- Qi asthenia and phlegm-stasis syndrome group had 50.61% (Qi stagnation of 11 cases had 13.25％、Qi ni of 8 cases had 9.64％、 blood asthenia of 7 cases had 8.43％、blood heat of 6 cases had 7.23％、water stagnation of 6 cases had 7.23％saliva asthenia of cases had 4.81％). 2) ① In Qi asthenia and phlegm-stasis syndrome group and all the non-Qi asthenia and phlegm-stasis syndrome group, CD3+、CD4+、CD4+/CD8