探讨血乳酸在儿童脓毒症发病过程中的作用.docVIP

探讨血乳酸在儿童脓毒症发病过程中的作用 ［ ］目的Y解深圳地区儿童脓毒症的流行病学规律，探讨血乳 酸对疾病严秉程度的评估价值。方法采用前瞻性资料搜集方法，收集 2014年1月1 口?2015年12月31 口期间入住南方医科大学附属深圳 妇幼保健院PICU，并诊断为脓毒症（包括严重脓毒症及脓毒性休克） 的患儿，共106例，分为普通组（单纯脓毒症）和严重组（入院诊断 或病程中发展为严重脓毒症、脓毒性休克），采用SPSS16.0软件进行 统计分析，比较不同阶段血乳酸在两组中的差异。结果本研究共纳入 脓毒症患者106例，同期PI⑶患者261例，占40. 6%，其中以1?3 月龄患儿发病率最高，约占43. 4%。其中肺炎为最常见原发病，共42 例（39.6%）,其次为急性泌尿系感染共28例（26.4%）。统计分析显示 严重组的乳酸在疾病不同时期与普通组有明显差异，有统计学意义 （P0. 05）o结论脓毒症是PI⑶的常见病，进展快，如得不到重视和 及时救治，可发展为严重脓毒症、脓毒性休克、甚至是多器官功能衰 竭、死亡，了解小?号O局5.牧餍胁OY鞑榧岸?态监测乳酸等早期预 警指标，积极选择治疗方案，有助于改善预后，减少死亡率。 和著作权归原 所右，如存不 愿意被转载的情况， 己 如果需要分享， 请保留本段说明。 ［关键词］乳酸；脓毒症；儿重 ［ ］R729 ［ ］A ［ ］2095-0616 (2017) 08-67-03 ［Abstract］ Objective To understand the epidemiological characteristics of children with sepsis in Shenzhen, and to explore the value of blood lactic acid in evaluating the severity of disease. Methods Prospective data collection methods was used. 106 cases of sepsis children (including severe sepsis and septic shock) cured in PICU of Shenzhen maternal and child health care hospital affiliated to Southern Medical University were selected. They were divided into common group (sepsis) and severe group (severe sepsis or septic shock developed during the course of diagnosis or progression) . SPSS16. 0 software was used for statistical analysis. The difference of blood lactic acid in two groups at different stages was compared. Results A total of 106 patients with sepsis were enrolled in this study, with PICU in the same period in 261 cases, accounting for 40. 6%. Among them： 1-3 month old children with the highest incidence, accounting for about 43.4%. Pneumonia was the most common primary disease, with 42 cases (accounting for 39.6%)， followed by acute urinary tract infection in a total of 28 cases (accounting for 26. 4%) . Statistical analysis showed that the severity of lactic acid in the different stages of the disease and the general group were significantly different , with statistical significance （P〈0.05） . Conclusion Sepsis is a common disease of PICU,