美沙拉嗪联合益生菌治疗溃疡性结肠炎38例的的疗效观察.docVIP

美沙拉嗪联合益生菌治疗溃疡性结肠炎38例的的疗效观察 　　[摘要] 目的 观察美沙拉嗪联合益生菌治疗溃疡性结肠炎的临床疗效，进一步为临床治疗提供参考依据。方法 将我院自2009年1月~ 2011年1月收治的76例确诊的溃疡性结肠炎患者随机分为联合组（美沙拉嗪联合益生菌治疗+常规治疗）和对照组（常规治疗）各38例，比较分析治疗后两组患者的疗效及不良反应情况。结果 治疗4周后，根据疗效标准显示，联合组的总有效率达94.74%以上，对照组的有效率达78.95%，两组总有效率经χ2检验处理，差异有显著性（P＜0.05）。两组患者治疗前后肝肾功能均未见明显异常。结论 美沙拉嗪联合益生菌治疗溃疡性结肠炎疗效确切，不良反应少，值得临床推广和应用。 　　[关键词] 溃疡性结肠炎；美沙拉嗪；益生菌 　　[中图分类号]R574.62[文献标识码] B[文章编号] 1673-9701（2011）25-91-02 　　 　　Mesalazine Combined with Probiotic for Ulcerative Colitis:An Effect Observation of38 Cases 　　TU Zhengyan1 LI Yumei 1 XU Wei2 　　1.Department of Gastroenterology,Daqing Oilfield General Hospital Group of Longnan Hospital in Heilongjiang Province the Fifth Affiliated Hospital of Qiqihar Medical College，Daqing 163453，China；2.Guangzhou Military Regin Air Force Logistics Clinic, Guangzhou 510052, China 　　 　　[Abstract] Objective To observe the effect of Mesalazine combined with probiotic in treating ulcerative colitis MethodsSeventy-six patients diagnosed with ulcerativewere randomly divided into combined group and control group with 38 cases in each group from January 2009 to January 2011 in our hospital,and the efficacy and adverse reactions were comparedafter treatment. ResultsAfter 4 weeks, according to the efficacy of the standard display, the combined groups total effective rate of 94.74% over the effective rate of 78.95% the control group of total effective treatment by the χ2 test, the difference was significant, （P＜0.05）.Two groups of patients before and after liver and kidney function were no obvious abnormalities. ConclusionMesalazine combined with probiotic for ulcerative colitis efficacy is better and adverse reactions is less, worthy of being popularized. 　　[Key words] Ulcerative colitis; Mesalamine; Probiotics 　　 　　溃疡性结肠炎（ulcerationcolitis，UC）是病因未明的一组非特异性肠道炎症，具有慢性过程、自动复发的特点，目前临床上治疗主要以抗炎和调节免疫反应为主。近年来研究发现，肠道菌群失调在溃疡性结肠炎（UC）患者的发病机制中起重要作用，因此，调节肠道菌群失调是治疗UC的新策略。2009年1月~2011年1月，我院应用美沙拉嗪联合益生菌治疗38例UC患者，取得较好效果，现报道如下。 　　1资料与方法 　　1.1一般资料 　　选取我院2009年1月~2011年