不同孕期胎儿感染梅毒螺旋体妊娠结局剖析.docVIP

不同孕期胎儿感染梅毒螺旋体妊娠结局剖析 　　 作者单位：221005 江苏省徐州市肿瘤医院 　　通讯作者：吕爱远 　　【摘要】 目的 探讨不同孕期胎儿感染梅毒螺旋体后的结局分析。方法 选取2006年1月～2011年4月于本院进行生产治疗的妊娠梅毒患者56例为研究对象，将其随机分为A组（≤12周治疗组）14例、B组（13～28周治疗组）14例、C组（≥29周治疗组）14例和D组（未治疗组）14例，将4组患者的足月分娩率、早产率、死胎率及低体重儿发生率、畸形率、Apgar评分及母婴RPR滴度进行检测及比较。结果 A组的足月分娩率高于B、C及D组，以D组最低，A组的早产率、死胎率及低体重儿发生率、畸形率均低于B、C及D组，以D组最高，母婴RPR滴度A组也最佳，A组中治疗2个疗程者母婴RPR滴度优于1个疗程者，差异均有统计学意义（P0.05）。结论 早期治疗对改善妊娠梅毒的预后有着积极的意义，因此主张早期治疗。 　　【关键词】 不同孕期胎儿； 梅毒感染； 妊娠结局 　　Pregnancy outcome of gestation fetal infected by treponema in different stages LV Ai-yuan,LIAO Hong-mei,JIA Zheng-wei.Tumor Hospital of Xuzhou , Xuzhou 221005,China 　　【Abstract】 Objective To investigate the pregnancy outcome of gestation fetal infected by treponema in different stages.Methods January 2006-May 2011 for production in our hospital treated 56 cases of syphilis for the pregnancy study were randomly divided into group A （≤12 weeks, treatment group, n14）, group B （13 to 28 weeks, n14）, group C （≥29 weeks, n14） and group D （n14） 14 cases, group A, B and C were treated, group D were not. Full-term delivery rate, preterm delivery, stillbirth rate and the incidence of low birth weight children, malformation rate, apgar score and maternal RPR titer were compared.Results Full-term birth rate in group A was higher than that of group B, C and D, the group D was the lowest. Preterm birth rate, still birth and low birth weight children the incidence of malformations in group A were lower than those of group B, C and D, the group D was the highest. Maternal RPR titer in group A was the best, of those who accepted 2 courses of treatment was superior to 1 cause. The differences were statically significant（P＜0.05）.Conclusion The early treatment could improve the prognosis of syphilis in pregnancy. 　　【Key words】 Gestation fetus of different stages; Syphilis infection; Pregnancy outcome 　　 梅毒是由梅毒螺旋体通过直接接触感染的具有高度传染性的性传播疾病，妊娠合并梅毒可通过胎盘引起宫内感染，导致流产、早产、死胎、新生儿死亡或先天梅毒儿出生，对围产儿危害极大，是高危妊娠的重点监护对象之一［1］。本文回顾分析了2009年1月～2011年4月在本院分娩的80例梅毒患者，现报道如下。