复心汤对心衰大鼠模型TNF-а与心肌细胞凋亡的影响.pdfVIP

and ascites formed gradually; lose of fur,and different hair color, part of the rats appear patchy hair removal, skin ulcers and necrosis. Compared with the model group, treatment groups have the similar symptoms later, and lighter. ② Rats cardiac function: Compared with the normal control group, model group rats average LVSP and ±dp/dtmax decrease significantly (P0.01), while the average LVDP increased significantly(P0.01). Compared with the model group, LVSP, LVDP, ±dp/dtmax of Fuxin Tang low dose group show no significant differences (P0.05); while Fuxin Tang high dose group show significant differences(P0.01). ③ Rats serum TNF-a level: Compared with the normal control group, model group rats serum TNF-a level are increased significantly(P0.01). Compared with the model group, the TNF-a level of Fuxin Tang low dose group decreased (P0.05); the TNF-a level of Fuxin Tang high dose group, and captopril group are significantly decreased(P0.01). ④ Pathological changes of myocardium in rats: Normal control group rats’ myocardial cell morphology, cytoplasmic, interstitial and horizontal ( vertical ) lines are normal. Compared with the model group, the myocardial tissue of rats are severely damaged, the nuclei arranges irregularly, part of the myocardial nuclear are pyknosis, and fragmentation, muscle fibers are derangement, and interstitial edema varies, change like cardiomyopathy presenting. Compared with the model group, the treatments group rat myocardial tissue morphology improve of different degrees. ⑤ The expression of Rat myocardial protein Caspase-8 and Bcl-2: Compared with the normal control group, the expression of model group rats myocardial protein Caspase-8 are significantly elevated (P0.01), the expres