肺磨玻璃样病变侵袭性相关因素剖析.docVIP

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肺磨玻璃样病变侵袭性相关因素剖析.doc

肺磨玻璃样病变侵袭性相关因素剖析

肺磨玻璃样病变侵袭性相关因素剖析   【摘要】 目的 探讨肺磨玻璃样病变(GGO)侵袭性的相关因素。方法 47例CT征象为肺部磨玻璃影的肺腺癌患者, 按照GGO实性成分最大径与肺窗测GGO最大径之比(R表示)分组, R≥0.5作为观察组(32例), R0.5作为对照组(15例)。对比两组患者的临床、影像、病理资料, 判断其侵袭性。   结果 两组患者病灶部位、直径、形状以及边界是否清晰情况比较差异无统计学意义(P0.05);观察组的边缘分叶和(或)毛刺比例、胸膜凹陷征以及空泡征比例明显高于对照组, 差异具有统计学意义(P0.05);观察组病理分期及胸膜侵犯率高于对照组, 差异有统计学意义(P0.05)。结论 GGO的病灶实性比例越高肿瘤侵袭性越强, CT征象对判断肿瘤侵袭性具有重要价值。   【关键词】 肺肿瘤;磨玻璃样病变;侵袭性;相关因素   DOI:10.14163/j.cnki.11-5547/r.2017.33.014   Analysis of related factors of invasiveness of ground glass opacity XING Jia-qiang, JI Guang-lei, XUE Mei, et al. Department One of Thoracic Surgery, Linyi Tumor Hospital, Linyi 276000, China   【Abstract】 Objective To discuss the related factors of invasiveness of ground glass opacity (GGO). Methods A total of 47 lung abrasion patient with CT findings of lung ground glass opacity were divided by ratio of the maximum diameter of GGO solid component to the maximum diameter of GGO measured by pulmonary window (R) into observation group (R≥0.5, 32 cases) and control group (R0.05). The observation group had obviously higher proportion of the marginal lobe and (or) burr, pleural indentation sign and vacuole sign ratio than the control group, and their difference was statistically significant (P0.05). The observation group had higher pathological staging and pleural invasion rate than the control group, and the difference was statistically significant (P0.05). Conclusion The higher the proportion of solid lesions in GGO, the stronger the invasiveness of tumor, and the CT signs shows important value in judging the invasiveness of tumor.   【Key words】 Lung tumor; Ground glass opacity; Invasiveness; Related factors   ?对肺部大多数GGO, 目前的诊疗水平很难做出科学、准确地诊断, 导致诊断延后。有研究发现[1]持续存在GGO为肺部恶性肿瘤的可能性较高。病变性质的模糊导致部分患者的治疗方案不明确, 可能丧失最佳治疗时机。肺腺癌患者表现为GGO的CT征象和病灶中实性成分的比例与肿瘤侵袭性有一定相关性[2]。为了更好地认识磨玻璃密度影, 本研究利用高分辨率计算机断层扫描获取GGO的薄层高分辨率图像, 分析GGO侵袭性的相关因素, 指导早期诊断和治疗, 以提高肺癌的早期检出率和治愈率, 并尽可能避免过度医疗。   1 资料与方法   1. 1 一般资料 选取2015年1月~2017年4月本院住院治疗CT有肺部磨玻璃影、术后病理诊断为肺腺癌的患者, 根据GGO实性成分最大径与肺窗测GGO最

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