阿托伐他汀联合曲美他嗪治疗冠心病临床效果剖析.docVIP

阿托伐他汀联合曲美他嗪治疗冠心病临床效果剖析 　　DOI：10.16662/j.cnki.1674-0742.2017.07.004 　　[摘要] 目的 分析阿托伐他汀?合曲美他嗪治疗冠心病临床效果。方法 方便选取2015年4月―2016年6月在该院就诊的92例冠心病患者，按照数字随机数字表法将患者分为对照组和试验组，每组46例患者；两组患者均行扩血管药、钙拮抗剂、抗血小板聚集、吸氧、利尿剂等常规治疗；对照组在以上治疗基础上给予阿托伐他汀治疗，实验组采用阿托伐他汀联合曲美他嗪治疗；对比分析两组患者临床治疗效果、血脂水平以及心绞痛发作持续时间。结果 ①对照组中，有9例患者无效，总有效率为80.43%；而实验组中，有3例患者无效，总有效率为93.48%；差异有统计学意义（P0.05）。②在治疗后，两组患者TC、TG、HDL-C和LDL-C血脂水平均显著的低于治疗前（P0.05）；在治疗后实验组TC、TG和LDL-C水平分别为（2.20±0.83）、（1.31±0.13）、（1.48±0.04）mmol/L，下降程度教对照组更为显著（P0.05）。③两组患者在治疗后心绞痛发作持续时间均显著的低于治疗前（P0.05）；治疗后实验组心绞痛发作持续时间为（3.18±0.70）min，显著的低于对照组（4.89±0.89）min（P0.05）。 结论 与单独的阿托伐他汀临床用药相比，阿托伐他汀联合曲美他嗪临床效果更好，降低TC、TG和LDL-C血脂水平更为明显，患者心绞痛发作持续时间更短，在临床中具有推广和应用的价值。 　　[关键词] 冠心病；阿托伐他汀联合曲美他嗪；血脂水平；心绞痛发作持续时间 　　[中图分类号] R541 [文献标识码] A [文章编号] 1674-0742（2017）03（a）-0004-03 　　Department of Analysis of Clinical Effect of Atorvastatin and Trimetazidine in Treatment of Coronary Heart Disease 　　WENG Lan1， TANG Hua-dong2 　　1.Department of Cardiovascular Medicine， Zhangzhou Hospital， Zhangzhou， Fujian Province， 363000 China；2.Department of Anesthesiology， Zhangzhou Hospital， Zhangzhou， Fujian Province， 363000 China 　　[Abstract] Objective To analyze the clinical effect of atorvastatin and trimetazidine in treatment of coronary heart disease. Methods 92 cases of patients with coronary heart disease in our hospital from April 2015 to June 2016 were conveniently selected and randomly divided into two groups with 46 cases in each， both group adopted the routine treatment of vasodilators， calcium antagonists， anti-platelet aggregation， oxygen inhalation and diuretics， the control group were treated with atorvastatin on the basis of the above， while the experimental group were treated with atorvastatin and trimetazidine， and the clinical treatment effect， blood fat level and angina pectoris attacks continuous time were compared between the two groups. Results In the control group， 9 cases were ineffective， and the total effective rate was 80.43%； in the experimental group， 3 cases were inef