蒽环类抗肿瘤药物的心脏毒性临床指标的相关性研究儿科学专业论文.docx

PAGE PAGE IV 蒽环类抗肿瘤药物的心脏毒性临床指标的相关性研究 中文摘要 2.BNP 在不同 ANTH 疗程中，均有升高，说明 BNP 可作为 ANT 化疗过程中心脏 毒性的观察指标。 3.EF 改变与 ANTH 存在相关性，提示 EF 改变可作为部分 ANTH 较高患者的早期 监测预警指标。 关键词：蒽环类药物；心脏毒性；白血病；脑利钠肽 作 者：管丽君 指导教师：严文华 英文摘要 蒽环类抗肿瘤药物的心脏毒性临床指标的相关性研究 Research on Cardiotoxicity Clinical Index of Anthracyline Abstract Objective To detect the creatine kinase-MB (CK-MB) , cardiac troponin I (cTNI), brain natriuretic peptide (BNP) in peripheral blood, and electrocardiography(ECG), ultrasonic cardiogram (UCG) changes before and after ANT chemotherapy, then discuss and evaluate the sensitive cardiotoxicity clinical index of ANT. Method 80 acute leukemia patients who were hospitalized in Soochow University Affiliated Children’s Hospital were recruited for this study. They were divided into two group according accumulated dose of anthracycline (ANTH): 21patients in Group ≤ 100mg/m2,59 patients in Group ＞100mg/m2. Index changes before and after ANT chemotherapy were evaluated, SPSS16.0 was used for correlation analysis. Results Relationship between ANTH and cTNI elevation 80 cTNI results were detected, 21 patients in Group ≤100mg/m2, 59 patients in Group ＞100mg/m2. Serum cTNI were all ≤0.04ug/L before chenmotherapy. Statistic on cTNI elevation cases of different ANTH: 1 case in Group ≤ 100mg/m2, 15 cases in Group ＞100mg/m2. There were no differences of cTNI elevation between different ANTH（P=0.056, P ＞0.05）. Relationship between ANTH and CK-MB elevation 77 cTNI results were detected, 18 patients in Group ≤100mg/m2,59 patients in Group ＞100mg/m2. Statistic on CK-MB elevation cases of different ANTH: 1 case in Group ≤ 100mg/m2, 7 cases in Group ＞100mg/m2. There were no differences of CK-MB elevation between different ANTH（P=0.67, P＞0.05）. PAGE PAGE VI 蒽环类抗肿瘤药物的心脏毒性临床指标的相关性研究 英文摘要 Relationship between ANTH and BNP elevation 75 BNP results were detected, 18 patients in Group ≤100mg/m2, 57 patients in Group ＞100mg/m2. BNP changes were detected before and after chem