非消化系统自身免疫性疾病合并肝损害的危险和或预测因素研究-消化内科专业论文.docxVIP

暨南大学 暨南大学硕士学位论文 非消化系统自身免疫性疾病合并肝损害的危险和/或预测因素分析 III III or immune effector molecules, which bring about pathological immune responses to the body’s own tissue or cells, leading to damage. Patients with non-autoimmune digestive diseases such as systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis are often associated with liver damage clinically. It is probable because of the key role which the liver plays in the process of immunomodulatory in autoimmune diseases and simultaneously different degrees of liver damage occurs. However, the etiology and mechanism of the hepatic dysfunction in these diseases is not yet entirely clear.The current studies suggest that the main reasons are: ① The autoantibodies and (or) sensitized lymphocytes acts on the tissues or cells where the target antigen is and cause damage. ②Drugs induce liver injury .③ Secondary infection , especially viral hepatitis occur to the liver because of the immunosuppressive agents used in the treatment processes. There are a few studies probing the liver injury caused by the non-digestive autoimmune diseases, they try to find out the risk factors and / or predictive factors of hepatic dysfunction in patients with non-autoimmune digestive diseases. However, existing researches have the following problems: the conclusions differ greatly or even reverse; the predictive factors included in each study are different , so it is difficult to generalize them in a certain disease; The credibility of certain current studies is inadequate because of their small sample and the various research indicators; The exclusion criteria of some researches is not rigorous enough; Some studies just detect the indicators of a certain disease, without analyzing the association between the indicators and the disease; Currently, there have been many researches on the related factors of lupus hepatitis abroad, but the incidence rate of this disease is still controversial, because the exclusio