磁性纳米催化剂CuFe2O4在氮杂环合成和苄醇氧化中的应用研究-化学专业论文.docx

摘要 摘要 Ab Abstract I万方数据 I 万方数据 II II 万方数据 摘要 氮杂环化合物广泛存在于药物、天然产物及具有生物活性的分子中，在药物的研制中 起着非常重要的作用。传统的合成方法往往存在底物适用性差、副产物多等缺陷。因此， 寻找新型、高效、实用的氮杂环化合物的合成方法成为有机合成的重点。 醇类化合物到相应醛的直接转化一直是有机合成的热点。但是传统的合成方法存在很 多的缺陷。例如，昂贵的金属催化剂、强碱、强氧化剂，同时产物中伴有金属污染等，这 些都阻碍了该类反应的适用范围。从绿色化学的角度出发，寻找一种新型、高效、可回收 的绿色催化剂仍是一大挑战。 我们按参考文献方法制备了纳米级催化剂CuFe2O4，并通过XRD、SEM、TEM等手段 对其结构进行了表征。本文以CuFe2O4为催化剂合成了氮杂环及芳香醛类化合物。 (1) 磁性纳米颗粒CuFe2O4催化合成氮杂环化合物 利用邻氨基苯酚及醛类为原料，以廉价、易得、催化活性强、可回收的CuFe2O4为催 化剂，绿色高效的合成了苯并恶唑、苯并咪唑、苯并噻唑类化合物。CuFe2O4催化剂在外 界磁力作用下可从体系中分离出来，研究表明：其催化活性在重复利用十次以上后几乎不 发生变化。 (2) 磁性纳米颗粒CuFe2O4催化合成芳香醛 我们发现了一种以CuFe2O4为催化剂高效、绿色的合成芳香醛的新方法。以水为溶剂， 在氧气条件下完成醇到相应醛的转化。重要的是，该类反应无需配体及强碱。 通过以上方法，合成了33种氮杂环化合物和15种芳香醛，并对其结构进行了表征。 关键字：催化剂，磁性纳米颗粒，苯并恶唑，氮杂环化合物，芳香醛 ABSTRACT N-Heterocycles widely occur in medicine, natural products, and biologically active molecules, and they play an important role in the design and discovery of new drugs. However the uneasily available precursors and undesired by-products limit their wide applications. Therefore, the development of novel, efficient and practical methods for heterocycle synthesis is an important goal in modern organic synthesis. Direct conversion of primary alcohols to the corresponding aldehydes is still a pivotal reaction in organic synthesis. However, most of these traditional oxidation processes might suffer from some drawbacks such as the rarity and price transition metal catalyst, ligand together with strong base conditions, metal contamination in the end products and undesirable stoichiometric oxidants, which should still impede their applications on a large scale. In view of the principles of green chemistry, the novel, efficient and recyclable catalysts is still challenging in the current chemistry. The copper(II) ferrite nanoparticles were prepared according to the literature procedure, and were characterized by X-ray diffraction, SEM and TEM. The copper nanoparticles were used to compound N-Heterocycles and aldehydes. Copper nanoparticles catalyzed synthesis of nitrogen, oxygen