腹膜后脂肪肉瘤诊治及预后相关因素分析-外科学(肝胆血管外科)专业论文.docx

万方数据 万方数据 Abstract Objective To summary the experience of retroperitoneal liposarcoma in diagnosis and management. To analyze prognostic factors associated with retroperitoneal liposarcoma. Methods 61 Patients with retroperitoneal liposarcoma were admitted to department of hepatobiliary surgery, affiliated hospital of Qingdao university and followed between January 1, 2000 and December 30, 2014. Data of patient, tumor and management was analyzed retrospectively. Results Median overall survival of patients with retroperitoneal liposarcoma after surgery was 81 months for the those with primary disease, 47 months for those with local recurrence and 9 months for those with metastasis. The 1 year overall survival for the group of primary disease, local recurrence and metastasis is 95.1%, 87.5%, 25.0% respectively, the 2 years overall survival is 92.3%, 62.5%, 0 respectively, the 5 years overall survival is 71.8%, 31.3%, 0 respectively. There is significant difference in overall survival among above three groups(Log-rank test:χ2=23.127,P0.001).Univariate analysis showed histological subtype, intraoperative hemorrhage and operation time were the influencing factors to the overall survival after surgery(P0.05). Multivariate analysis demonstrated status of tumor resection(P=0.038 ， RR=4.21), histological subtype(P=0.027 ， RR=3.01)and intraoperative hemorrhage(P=0.035,RR=7.72)were independent risk factors for the overall survival after surgery. The median disease free survival of patients with retroperitoneal liposarcoma after surgery was 36 months. The disease free survival of 1 year, 2 years and 5 years was 90.6%, 69.2% and 24.2% respectively. Univariate analysis showed histological subtype, histologic grade, intraoperative hemorrhage and operation time were the influencing factors for the local recurrence after surgery(P0.05). Multivariate analysis demonstrated histological subtype(P=0.002，RR=1.85) and diameter of tumor(P=0.