肝细胞癌中胰岛素样生长因子1受体及血管内皮生长因子的表达及意义-病理学与病理生理学专业论文.docxVIP

万方数据 万方数据 平高、低组间比较，复发率及转移率差异均有统计学意义（P0.05），而生存率差 异无统计学意义（P0.05）。结论：1. IGF-1R 及 VEGF 可能促进了 HCC 的发生和 发展。 2. IGF-1R 及 VEGF 可能促进了 HCC 内微血管生成并与肿瘤的复发及转移 密切相关，可用于 HCC 的预后评估。 【关键词】 肝细胞癌；胰岛素样生长因子1受体；血管内皮生长因子；免疫组织 化学；预后 III The significance of insulin-like growth factor 1 receptor and vascular endothelial growth factor expression in hepatocellular carcinoma Major: pathology and pathophysiology Postgraduate:Yu Mengyi Supervisor:Professor Cheng Yuanhua [Abstract] Objective: To investigate the expression of insulin-like growth factor receptor （ IGF-1R ） , vascular endothelial growth factor （ VEGF ） and their relationships between clinicopathologic features in hepatocellular carcinoma（HCC）. Methods: Immunohistochemical EnVision method was utilized to detect the expression of IGF-1R and VEGF, MVD was marked by antibody CD34 and counted. The follow-up data of the cases of HCC was analyzed by Kaplan-Meier method for survival with log-rank test. Results:（1）In 51 cases of HCC, IGF-1R protein showed a high expression in 34 cases（66.7%）and low in 17 cases（33.3%）; while the tumor-adjacent tissues showed a high expression of IGF-1R protein in 20 cases （39.2%）low in 31 cases（60.8%）, the difference was statistically significant （P0.05）（. 2）Expression of VEGF protein in the carcinoma tissues was higher in 38 cases（74.5%）, and low in 13 cases（25.5%）; the tumor-adjacent tissues had a high expression of 21 cases（41.2%）and low expression of 30 cases（58.8%）, there was significant difference between them（P0.05）.（3）In 51 cases of HCC , the number of IGF-1R,VEGF protein overexpression in histological gradeⅢ+Ⅳwas significantly more than in gradeⅠ+Ⅱ（P0.05）; in TNM stageⅢ+Ⅳwas significantly more than in the stagⅠ+Ⅱ （ P0.05 ） , moreover , the vascular infiltration group was significantly more than group without vascular invasion（P 0.05）. But there was no significant difference between different tumor size, different gender, age, alcohol intake history, HBsAg, AFP, tumor num