低剂量肝脏CT灌注成像分析-影像医学专业论文.docx

低剂量肝脏 低剂量肝脏 CT 灌注成像研究 4 4 the differences between liver diseases and low doses normal control group. Results: Liver CTPI with different tube-current acquired relatively satisfied image quality and perfusion parameters. There was no significant difference between the means of perfusion parameters of corresponding ROI (P 0.05). HPI of Conventional-dose group (t = -2.23, P = 0.034) and MTT of low-dose group (t = -2.25, P = 0.042) had slightly difference between different ROI selection methods. And the rest perfusion parameters in each group obtained with ROIL and ROIS had no significant difference, P values greater than 0.05. The effective dose of conventional-dose, middle-dose and low-dose liver CTPI were 19.62mSv, 12.61mSv and 7.01mSv, separately. Compare with conventional-dose, low-dose liver CTPI acquired with about 64.27% reduction in radiation dose. HPI of fatty liver is higher than normal control group. HBF, HBV, HAP and HPI of liver metastases are higher than the normal control group. HBF, HBV, HPI, PS and HAP of hepatic hemangioma are higher than the surrounding normal tissue. HBF, HBV, HPI, PS, HAP, and PVP of hepatocellular carcinoma are higher than the normal control group. HBF and PVP of low-density necrosis areas of HCC are lower than the substance part of HCC. Conclusion: The low-dose and conventional-dose liver CTPI receive the same results of perfusion parameters. Different ROI selection method can affect the perfusion parameters. We should select the ROI as large as possible while avoid visible blood vessels. Compared with conventional-dose, low-dose liver CTPI acquired with 2/3 reduction in radiation dose. Low-dose liver CTPI can reflect the hemodynamic change of different liver diseases. CTPI has potential clinical value for diagnosis and differential diagnosis of liver diseases. KEY WORDS：X-ray computed Tomography, Low-dose, Perfusion imaging, Liver disease 1 1 主要符号说明 ROI: region of interest，感兴趣区 HBF: hepatic blood flow， 肝血流量， 单位 :（ ml/min·100g