蜚蠊提取液治疗皮肤慢性溃疡的研究-中医外科学专业论文.docx

PAGE PAGE 10 Abstract Objective: chronic skin ulcer is a common 、refractory disease with long course.it makes patients suffer great physical and psychological pain.At present, it,s difficult to heal the chronic skin ulcer ,and the healing mechanism is not completely clear. This research aims to explore the mechanism of healing of chronic ulcer of skin from the level of molecular biology by laboratory and clinical research on the chronic skin ulcer.To further explore the working target of Chinese medicine treatm- ent, meanwhile,to confirm the effectiveness of cockroachextract liquid in treatment of chronic skin ulcer with objective data. The ultimate aim is to provide laboratory basis and data support for seeking the effective、convenient and inexpensive treatment of chronic skin ulcer. Methods: 68 sufferers who meet the inclusion criteria of chronic skin ulcer were randomly divided into experimental group and control group. the Infected patients should be given anti-infection treatment, the patients with diabetesmellit-us can also take hypoglycemic agents. clean the ulcer with physiological saline cotton, then wipe the ulcer with dry cotton, the experimental group sufferers were treated with cockroach extract liquid wet compress （Kangfuxin liquid）,while spread the Shengjisan over the ulcer surface of control group sufferers, finally bandaged ulcer the with sterile gauze. The two groups were changed dressing everyday, for 4 weeks. To observe the healing course and cure rate. Before and after the treatment , took the skin lesions tissue samples of the two groups,the expression of Smad3 gene、TGF-β1 and VEGF was examined by immunohistochemistry method. Results: Before treatment, the skin lesion area 、 the score of Secretion 、the score of skin lesions clour、the score of skin lesions odor 、the score of soreness and asting plasma glucose level of both experimental group and control group were comparable ,with no significant difference（P＞0.05