载药聚乙烯醇海藻酸钠静电纺丝纤维的改性及其药物体外释放研究谢.docVIP

载药聚乙烯醇/海藻酸钠静电纺丝纤维的改性及其药物体外释放研究 谢 红1，卢来春2，管海燕2，黄 华1 (400016重庆，重庆医科大学药学院药剂学教研室1；400042重庆，第三军医大学大坪医院野战外科研究所药剂科2) [摘要] 目的 将聚乙烯醇(PVA)/海藻酸钠(SA)静电纺丝纤维进行改性制备具有良好性能且能缓慢释放药物的伤口敷料。方法 采用戊二醛蒸汽、3%氯化钙无水乙醇溶液和3%氯化钙饱和硼酸溶液对PVA/SA静电纺丝纤维进行交联后，以溶胀率为指标筛选出最佳的交联剂。以3%氯化钙无水乙醇溶液为交联剂，分别制备了交联时间为1、3和20h的改性盐酸莫西沙星(MH)/PVA/SA静电纺丝纤维，然后对制备的纤维药物体外释放情况进行释放介质？了分析。结果 通过筛选得知3%氯化钙无水乙醇溶液为最佳交联剂，其交联的纤维溶胀率为108%。在随后的MH/PVA/SA静电纺丝纤维药物体外释放实验中，我们发现随着交联时间的增长，药物释放越缓慢结果较简略，补充重要实验结果和数据。结论 采用3%氯化钙无水乙醇溶液为交联剂改性的PVA/SA静电纺丝纤维耐水和溶胀性能良好，将更适合于用作难愈合且有渗出液伤口的敷料。 释放介质？ 结果较简略，补充重要实验结果和数据 [关键词] 静电纺丝纤维；交联剂；溶胀率；体外释放 [中图法分类号] [文献标志码] A [通信作者] 黄 华，电话：(023)E-mail: huangh6001@163.com Modification of polyvinyl alcohol/sodium alginate electrospun nanofibers loaded drug and Approach on its drug release in vitro Xie Hong1, Lu Laichun2, Guan Haiyan2, Huang Hua1 (1College of Pharmacy, Chongqing Medical University, Chongqing, 400016; 2Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China) [Abstract] 对照中文修改Objective To prepare wound-dressing that has good properties and can slowly release drugs using the modified polyvinyl alcohol (PVA)/sodium alginate (SA) electrospun nanofibers. Methods After PVA/SA electrospun nanofibers were cross-linked by glutaraldehyde vapor, 3% calcium chloride/ethanol solution and 3% calcium chloride/saturation boracic acid solution, the optimal cross-linker was screened out using swelling ratio as the index. Using 3% calcium chloride/ethanol solution as the cross-linker, 1-, 3- and 24-h-cross-linked moxifloxacin hydrochloride (MH)/PVA/SA electrospun nanofibers were modified, and then their drug release in vitro was analyzed. Results By the screening experiment, 3% calcium chloride/ethanol solution was found to be the optimal cross-linker. The swelling ratio of the nanofibers modified with this cross-linker was 108%. In the subsequent drug release in vitro of MH/PVA/SA electrospun nanofibers, we found