如何提高小儿麻醉安全性.pptVIP

* Neurokinin: 神经激肽-1 降钙素基因相关肽(calcitonin gene-related peptide, CGRP) * Both term and premature neonates do not have a well developed glucuronidation system Clearance values for morphine reached adult level by 2 mo Usual iv: 0.1 to 0.2 mg/kg * Condition that compromises liver blood flow in children (eg, increased intraabdominal pressure, increased positive end-expiratory pressure, cardiac disease, or the use of vasopressors) increases the variability of the drug’s clearance and consequently prolongs the elimination half-life The clearance is decreased and the half-life of fentanyl is prolon