临床医学毕业中链甘油三酯对糖尿病患者体重和体脂的影响研究.docVIP

XX大学 毕业论文 中链甘油三酯对糖尿病患者体重和体脂的影响研究 2014年6月25日 【摘要】目的 观察中链甘油三酯(MCT)干预对2型糖尿病(T2DM) 患者体重和体脂的影响。方法 将糖尿病患者分为MCT组、MCT/LCT组和LCT 组，在接受食物交换份法的膳食宣教、总能量和脂肪摄入量得到控制的基础上， 每天分别食用不同组成的食用油30ml,连续食用12周。在0和12周时进行膳 食调查和评价。在0、6周和12周时测量空腹血糖、卩一瓮基丁酸、身高、体重、 腰围和臀围，计算体质指数(BMI)和腰臀比(WHR)。结果 在12周时MCT/LCT 组摄取的总能量、蛋白质量和脂肪量比LCT组低，MCT/LCT组摄取的脂肪量也 比MCT组低。在0、6和12周时，3组的空腹血糖和卩一疑基丁酸差异均无显 著性。相比LCT组，6周和12周时MCT组和MCT/LCT组的体重、BMI均较 低，腰围也明显较小。12周吋MCT组的WHR明显小于LCT组的WHRy结论 在总能量和脂肪摄入量得到控制的基础上，用MCT取代100%或50%的膳食油 脂，具有降低T2DM体重、腰围和腰臀比的减肥作用，对患者的空腹血糖和卩 —疑基丁酸没有影响。 【关键词】 MCT； 2型糖尿病；肥胖；体重；BMI； WHR The effects of MCT on obesity in type 2 diabetes [Abstract ] Objective To observe the effects of MCT on body weight and body fat in type 2 diabetics.Methods T2DMs were divided into MCT group, MCT/LCT group and LCT group.With total energy and fat consumption controlled, they were given different proportion test oil after receiving education of food crossover method.All patients were told to take the test oil everyday for 12 weeks.We did diet survey and evaluation during 0 and 12 wk.We also detected fasting plasma glucose(FPG), P-hydroxybutyric acid(BHBA) and measured body height, body weight, waist line and hip line at 0 wk, 6 wk and 12 wk.Then BMI and WHR were analyzed.Results Compared with LCT group, total energy, protein and fat consumption in MCT/LCT group were decreased.MCT/LCT group also had lesser fat consumption than MCT group.There were no significant differences on FPG and BHBA among three groups.Compared with LCT group, body weight, BMI and wais tline of 6wk and 12 wk in MCT and MCT/LCT groups were decreased and WHR of 12 wk in MCT group was much decreased. Conclusion With total energy and fat consumption controlled, the daily diet oil is replaced full or partly by MCT, the body weight, BMI and WHR decrease on T2DM patients, implicating that MCT helps to prevent obesity.No influence for FPG and 卩HBA level on T2DM. ［Key words］ MCT； T2DM obesity； body weight MI； WHR 2型糖尿病(T2DM)患者通常比非糖尿病者具有更高的体重，减轻体重 可降低T2DM发生冠心病等并发症的危险性［1］。