超临界流体技术制备纳米布洛芬与其与多孔材料的复合制剂.pdfVIP

Abstract PEG2000toPEG6000)，and increaseswiththeflowrateofthe significantly gas—saturated solutionorthe in contentthe the ibuprofen mixture，while ibuprofen／PEG6000 temperature showslittleeffectonthesizeinthe eutectic of investigatedrange．The composition doesnotshow effectonthe sizeor ofthe PEG6000一ibuprofen special particle morphology obtainedfromthe producedibuprofennanoparticles．Theibuprofennanoparticles modified PGSSTM-basedshowmuchfasterdissolutionratethanthe raw material process ibuprofen andthe fromadirect inthesimulated ibuprofenparticles mixingprocess gastricjuice acidand chloridebuffersolutionwith (hydrochloricpotassium intestinal buffersolutionwith simulatedcontinuous fluid(phosphate pH=7．2士0．02、and dissolution． The ratioof intwo and loading ibuprofenloadingmaterials，viz．Si02 (13-CD)Was undervarious time，loadingand investigated conditions(10adingpressure asolute—saturated fluid loadingtemperature)byusing supercritical at showedthatthesaturatedtime 5．0 technique．Results loading highpressure(1MPa)and low lessthan15hand20h the pressure(8．0MPa)are respectively；a