健胃合剂对非甾体类消炎药胃粘膜损伤保护作用的研究-内科学(消化系)专业论文.docxVIP

24小时禁食，前12小时禁水。3．观察指标：测定粘膜血流，肉眼观 24小时禁食，前12小时禁水。3．观察指标：测定粘膜血流，肉眼观 察胃粘膜改变；测定6-keto．PGFl。，TXB2、ET-1的含量，光镜下观 察病理改变。 结果：阳性药物对照组和健胃合剂组大鼠胃粘膜损伤较造模对照组有 明显改善，健胃合剂组和阳性药物对照组中GMBF、6-keto．PGFl。、 TXB2较造模对照组有明显增高，而健胃合剂组的ET-1较阳性药物对 照组和造模对照组有明显的下降。 结论：健胃合剂可以明显改善NSAIDs胃粘膜的损害，除提高GMBF 及6-keto-PGFl。和TXB2的含量外，更降低了ET-1的含量，表明健胃 合剂更能从多途径保护胃粘膜。 关键词：健胃合剂，非甾体类消炎药，胃粘膜保护 A A research of protective effects of Jianwei Mixture on gastric mucosa injured by NSAIDs Medical College， Internal Medicine Zhejiang University (Gastroenterology) postgraduate Xu jianjnn Tutor Prof．Ji feng Abstract Objective：In search of a new and more effective sort of herb product for protecting gastric mucosa lesions induced by NSAIDs(Non Steroidal Anti-inflammatory Drugs)，we studied the role of JianWei Mixture in preventing NSAIDs—induced gastric lesions by analyzing histomorphology,mucosal blood flow,6-keto—PGFta，TXB2 and ET-1 within rat models．On the basis of this study,the effect of JianWei Mixture to relieve NSAIDs—induced gastric lesions has been estimated， and the mechanism of protective function is explored as well Methods： 1．Animal categorization：In this experimentation，60 SD rats were randomly divided into 6 groups that contained 1 0 rats each． 2．Establishment of animal models：All these 6 groups were designed for different purposes．BdeflyGroup 1(negative control group)，normal saline 2ml／1 OOg；Group 2(modeling control group)，normal saline 2ml／1 2ml／1 009 either；Group 3(positive control group)，Sucralfate solution 2ml／1009；Group 4(10w does group of JianWei Mixture)dianWei Mixture lml／1009；Group 5(medium does group of JianWei Mixture)，JianWei Mixture 1．5ml／1009；Group 6(high does group of JianWei Mixture)，JianWei Mixture 2ml／1 009．In seven days the rats were orally administered with relative drugs once time for each day,The rats of Group 2-6 accepted oral administration of Asprin(100mg／kg)in 30 minutes．Animals were withheld oral food for 24hrs and water for 12hrs before last oral administration． 3．Observation i