健脾美肤散联合净面方治疗脾虚湿蕴型小儿湿疹的临床疗效观察-中医外科学(医学美容)专业论文.docxVIP

万方数据 万方数据 中文摘要 目的:1、探讨健脾美肤散联合净面方治疗脾虚湿蕴型小儿湿疹的临床疗效和对皮 肤美、皮肤屏障功能的影响。 2、探索小儿湿疹的中医发病机制，探讨“健脾美肤散”和“净面方”的组 方规律。 3、依据经验方确立治疗小儿湿疹的临床路径与方案，利于临床推广。 方法:将符合本课题的 77 例脾虚湿蕴型小儿湿疹的患者随机分为治疗组和对照 组，治疗组 40 例，对照组 37 例。两组均采用净面方外洗,治疗组以健脾美肤散 内服，对照组以氯雷他定颗粒口服，两组均采用皮肤屏障功能检测，被测者于检 测前清洁待测皮肤，于室温 20 一 24℃，湿度 40％～60％的房间内,静息 10～ 20min 后，分别检测前臂伸侧、脸颊、躯干、胫前 4 个皮损部位的经表皮水分丢 失(TEWL)、角质层含水量，每个部位连续测量 3 次，取平均值为每个受试者的测 量值，每周复诊 1 次,4 周为 1 个疗程，于治疗后 15 天、30 天时观察患者治疗前 后皮损面积、EASI 评分、瘙痒、中医症候评分；治疗前后经表皮水分丢失(TEWL)、 角质层含水量的值，对痊愈患者一个疗程时观察皮肤色素沉着、光滑度评分并随 访 6 个月，观察记录指标。 结果:1、本次临床试验表明治疗组在改善患者皮损面积、降低 EASI 积分、瘙痒、 中医症候评分、复发率等方面均明显优于对照组(P0.05)。 2、对经表皮水分丢失(TEWL)、角质层含水量以及皮肤的色素沉着、光滑度 改善方面治疗组优于对照组(P0.05)。 结论：本次临床试验表明健脾美肤散联合净面方治疗脾虚湿蕴型小儿湿疹具有较 好的临床疗效和恢复皮肤美、改善皮肤屏障功能的作用。可归纳总结出专病专方 的临床路径与方案，值得临床运用和推广应用。 关键词：小儿湿疹；脾虚湿蕴型；健脾美肤散；净面方；皮肤屏障功能；皮肤美 的恢复 1 Abstract Objective: One:To explore clinical effect of infantile eczema with spleen defficiency damp retention treated by Jianpi Meifu San and Jingmian Fang and skin beauty, skin barrier of function. Two:To explore the TCM pathogenesis of infantile eczema, explore the formula rule of Jianpi Meifu San and Jingmian Fang. There:Based on the experience of clinical path and establish regimen in the treatment of infantile eczema, conducive to clinical practice. Methods： This topic will comply with the 88 cases of spleen defficiency damp retention infantile eczema patients were randomly divided into treatment group and control group, each of 44 cases. Two groups use the net surface wash, treatment group with tonifying spleen and texture of skin powder, the control group with oral loratadine, two groups use the skin barrier function detection, measured by the detection of pre tested on clean skin, from 20 to 24℃, humidity 40% ~ 60%, 10 ~ 20min after resting, were detected in the forearm extensor side, flexor aspect of forearm, cheek, anterior tibial 4 skin lesions of transepidermal water loss (TEWL), water content of stratum corneum, each site was measured 3 times, average measurements for each subject val