姜黄汤抗肿瘤及对化疗药减毒增效作用的研究-中药学专业论文.docxVIP

y y 464 968 中文摘要 本课题根据中医理论对肿瘤及化疗毒副作用病因和病机的认识，结合中医 临床经验。以经验方姜黄汤为研究对象，进行了以下三个方面的理论和实验工 作：其一，“活血益气”是中医治疗肿瘤的法则，本方是这一指导原则的具体体 现，也是本方取效的关键。其二，以化疗药驱邪(抑瘤)力强的优势补充中药 驱邪(抑瘤)力较弱的不足，以中药扶正优势减轻化疗药的霉副作用及肿瘤细 胞的耐药性，中药与化疗药联用，可以优势互补。其三，对该方进行了较为全 面深入的实验研究，结果表明：(1)该方有明显的抗s。舯、如肿瘤作用，与化 疗药环磷酰胺联用，有明显的增效减毒作用；(2)该方的抗肿瘤作用、对化疗 ————————一_、————，—一 药增效减毒作用与多方面机理有关。(主要包括：有效成分直接对肿瘤细胞的杀 、————————-——————一 伤作用，对化疗药的协同作用，逆转肿瘤细胞耐药性的作用，增强机体免疫功 、 能的作用，对骨髓细胞的保护作用，对血虚动物生活质量的改善作用等。＼j 。——、——_’+。+’一 ／ )(关键词：抗肿瘤化疗增效减毒机理 AbstractThis Abstract This sclmv is base oil understand of traditional medical theory about tlllnor’s etiological factor and side-effect ofchemical．The object ofthis study is Soup Jiang Huang．The theoretic and experhm删research include three sections as follow： First，pDomoting blood circulation and Supplementing qi are the therapeutic prhnciple of traditional chinese medicine for treatmg ILIHlOr．This prescription is specific presentation of the rule，as well as the key of obtaining effects in treating tumor． Second,clz．mical has superiority of high killing tulnor rate，which carl complemem deficient of tradition medicine．Tradition medicine has superiority of strengthening the body resistance，which can reduce side-effect of chemical． Therapeutic alliaI虻e of tradition medicine and chemical has virtue of complememation,which is fit南r tradiuMn medical theory ofcuring tunloltoo． Third，we did experimental studies widely and deeply OR Soup Jiang Huang,the remits showed that：(1)The Soup Jlang Huang has action of killing tumor and reducing chemical poison and strengthening the body resistance．(2)The action is associated with many ways，which include killing tulllor cells directly and strengthening body’s immunity．The medicine can improve living-qualay of blood deficiency animals．Having synergistic action with chemical，and it can invert tolerance oftanrer，and so on． Key Word：anti-tamer chemical increasing·effect attenuation mechanism 硕士学位论文 硕士学位论文 姜黄汤抗肿瘤及对化疗药减毒增效作用的研究 引 言 目前，据专家估计，世界上每年死于癌症的患者超过500万人，我