姜黄治疗寻常型银屑病的临床疗效及外周血免疫学指标变化-皮肤性病学专业论文.docxVIP

中文摘要 中文摘要 姜黄治疗寻常型银屑病的临床疗效及外周血免疫学指标变化 摘 要 目的观察姜黄治疗寻常型银屑病的l临床疗效，及其对外周血CD4+，CD8+，CD25+T 淋巴细胞和sIL一2R水平的影响。探讨细胞免疫与银屑病发病的关系及姜黄对银屑 病的治疗作用。 方法根据入选标准随机选取30例临床上已确诊为寻常型银屑病的患者，口 服姜黄煎剂8周，采用PASI积分观察治疗前后患者皮损的变化。采用流式细胞术 检测患者治疗前后外周血中CD4+，CD8+，CD25+T淋巴细胞数量，并以本流式细胞仪 标准值为正常对照。采用酶联免疫吸附试验(ELISA)双抗体夹心法检测患者治疗 前后及正常对照者血清中sIL一2R水平。 结果与正常对照组相比，寻常型银屑病患者外周血CD8’，CD25+T淋巴细胞及 赢清sIL一2R水平明显升高，CD4VCD8+比值明显降低；患者口服姜黄煎剂治疗后， 皮损明显好转，PASI积分明显下降(PO．01)；外周血CD8+，CD25+T淋巴细胞及血 清sIL一2R水平明显降低，CD4+／CD8+比值升高，且CD25+T细胞及sIL一2R与患者皮损 严重程度明显相关。 结论寻常型银屑病患者细胞免疫功能存在异常，T淋巴细胞亚群特别是CD8+T 细胞在银屑病的发病过程中可能发挥着重要的作用。姜黄对寻常型银屑病患者的皮 损有明显疗效，可能通过调节细胞免疫而发挥作用。CD25+T细胞和sIL一2R水平与 患者皮损严重程度密切相关，随病情的好转明显下降，对疗效的评价具有一定的参 考价值。 【关键词】 姜黄；寻常型银屑病；T细胞亚群：可溶性白介素一2受体；PASI 硕士研究生； 张 勇 导 师： 肖君刚 英文摘要Clinical 英文摘要 Clinical Effects and Changes ofPeripheral Blood Immunology Indicator in the Treatment of Psoriasis Vulgaris with Curcuma ABSTRACT Objective To observe the clinieal effects and changes of CD8+，CD4+，CD251 eell subpopulations and slL一2R in the peripheral blood in the treatment of psoriasis vulgaris with curcuma，and to study the role of cell immunity in the pathogenesis of psoriasis and the therapeutic effects of curcuma on psoriasis vulgaris． Methods Thirty psoriasis vulgaris patients selected randomly had been treated with the decoctum of curcuma for eight weeks．PASI scores was used to evaluate the clinica]therapeutic effect on patients’lesions． CD8+．CD4+，CD251 cell subpopulations in the peripheral blood of patients were detected by flow cytometer and double antibody sandwich enzyme一1 inked immunosorbant assay(ELISA)was used to study the level of slL一2R in the serum of patients before and after treatment． Results The level of CD8+，CD25“r iymphocytes and sIL一2R were significantly higher and the ratio of CD4+／CD8+T cells was lower in the peripheral blood in patieats than that in control group．PASI scores and the 1evel of CD8+ lympbocytes decreased obviously and the ratio of CD4+／CD8+T cel Is increased in patients with psoriasis vulgaris after