结核性脑膜炎患者LTA4H基因多态性研究-神经病学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要············································································································1 英文摘要············································································································5 英文缩写···········································································································9 研究论文 结核性脑膜炎患者 LTA4H 基因多态性研究 前言··········································································································10 材料与方法······························································································12 结果··········································································································18 附图··········································································································21 附表··········································································································24 讨论··········································································································29 结论··········································································································33 参考文献···························································································34 综述 结核性脑膜炎易感基因的研究······················································37 致谢··················································································································49 个人简历··········································································································50 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 结核性脑膜炎患者 LTA4H 基因多态性研究 摘 要 目的：结核性脑膜炎（Tuberculous meningitis，TBM）简称结脑，是 由结核分支杆菌（Mycobacterium tuberculosis，Mtb）引起的中枢神经系统 非化脓性炎症，是结核病中最严重的形式，死亡率和致残率很高。据统计 全世界约 1/3 人口感染 Mtb，其中 10%的感染者发展为结核病，仅 1%发 展为 TBM。临床上不同个体暴露在相同的病原学条件下患者罹患结核病 的形式差异很大，大部分患者发生肺结核，只有一小部分发生结脑，并且 不同结脑患者的临床表现及预后也有很大差异，提示宿主基因在结核性脑 膜炎的发生发展中起到重要作用。在感染 Mtb 患者中，涉及到杀伤结核 杆菌的免疫应答基因的突变，可能使得 Mtb 更容易由肺部扩散到脑组织 从而引发结脑，而据文献报道白三烯 A4 水解酶（LTA4H）基因在涉及机 体对结核