网膜素1与急性脑梗死相关性研究.docxVIP

网膜素J与急性脑梗死相关性研究 孙婷12孔庆霞3 （1天津医科大学研究牛院300070） （2山东省济宁市第二人民医院神经内科272000） （3济宁医学院附属医院272000） 【摘要】目的：研究网膜素J在急性脑梗死患者中的表达，探讨网膜素与急 性脑梗死，尤其是动脉粥样硬化性脑梗死的相关关系。方法：连续性收集180 例急性脑梗死患者，根据颈动脉彩超分为无动脉粥样硬化组（A组）、稳定型斑 块组（B组）及不稳定型斑块组（C组）。酶联免疫吸附法（ELISA）检测血清网 膜素水平。另取健康体检者180例作为对照。分析网膜素J在急性脑梗死患 者中的表达。结果：网膜素J在急性脑梗死患者中显著低于健康对照人群 （Plt;0.05）；在B组及C组患者中显著低于A组（Plt;0?05, Plt;0?05）,而在B 组及C组之间无显著性差异（Pgt;0.05）o结论：血清网膜素在急性脑梗死患 者中表达显著降低，将来可能成为一种新的急性脑梗死诊断、严重程度及预后的 判断指标。 【关键词】网膜素急性脑梗死动脉粥样硬化脂肪因子 【中图分类号】R743 【文献标识码】A 【文章编号】2095-1752 （2013） 13-0388-03 Differential expression of omentin?l in acute cerebral infarction and different subtypes 【Abstract】 Objective: To investigate the differential expression pattern of omentirvl in acute cerebral infarction and different subtypes, and to explore the relati on ship betwee n omenti and acute cerebral infarctio n, especially atherosclerotic cerebral in fa ret i on. Methods: A total of 180 patients with acute cerebral infarction were enrolled consecutively. They were divided into no atherosclerosis group (group A), stable atherosclerosis group (group B) and unstable atherosclerosis group (group C) by carotid arterial color Doppler ultrasound. Serous omentin-1 was detected by enzyme linked immunosorbent assay (ELISA). A total of 180 healthy members were enrolled as control group? The differential expression pattern of omentin-1 in acute cerebral infarction and different subtypes was analyzed. Results: The serous ome ntirvl level in acute cerebral in fa ret i on patie nts was significantly lower than the control (Plt;0.05). The omentin?l in group B and group C was lower than in group A (Plt;0.05, Plt;0.05), while the difference between group B and group C was not significant (Pgt;0.05).. Conclusions: Omentirvl was differentially expressed in acute cerebral infarction and subtypes, and it may become a no vel biomarker for diag nosis and prog nosis in the future. 【Key words】omentinacute cerebral infarction atherosclerosis adipokine 脑梗死是一种最常见的引起神经功能障碍的脑血管疾病，其最主要的病 因是动脉粥样便化