摘要-食品科学系-国立屏东科技大学.DOCVIP

國立屏東科技大學食品科學系碩士班 研究生專題報告書面摘要 題目：綠咖啡豆萃取物對於脂肪代謝的影響 指導教授：謝寶全 老師 Effects of green coffee bean extract on 報 告 者：劉玟君 lipid metabolism. 報告日期：200 摘要 根據世界衛生組織報告，2005年全球有十六億人口體重過重，有四億人口肥胖，且數量持續增加。肥胖與許多疾病有關，如糖尿病、心血管疾病、高血壓及癌症等，因此，如何預防肥胖發生，成為現今社會重要的健康議題。 綠咖啡豆中含有許多酚類化合物，如氯原酸(Chlorogenic acid,CGA)，研究指出，氯原酸可透過過氧化體增殖劑活化接受器(Peroxisome Proliferator-activated Receptor-α, PPAR-α)影響脂肪代謝。PPAR-α為一細胞核接受器，當其活化時，會增加脂肪酸氧化酵素的活性，提升脂質代謝利用。氯原酸可藉著增加PPAR-α之mRNA及蛋白質表現，而達到調節脂肪代謝的效用。 近年來，學者以綠咖啡萃取物及氯原酸進行動物試驗，發現其可減緩實驗動物的體重增加，降低血清膽固醇及脂肪酸含量，減少內臟脂肪堆積，由此可知，綠咖啡豆萃取物有助於肥胖症的預防及治療。 關鍵字：綠咖啡豆萃取物、氯原酸、脂肪代謝 Abstract World Health Organization’s reports indicated that there were approximately 1.6 billion adults overweight, and at least 400 million adults were obese globally in 2005. Obesity is associated with risks of a number of conditions, including diabetes mellitus, cardiovascular disease, hypertension, and certain cancers. Therefore, how to prevent obesity becomes an important healthy subject. A lot of polyphenols are in green coffee beans, such as Chlorogenic acid (CGA). CGA might modulate lipid metabolism through Peroxisome proliferator-activated Receptor-α(PPAR-α). PPAR-α is a kind of nuclear receptor. When activated, PPAR-αcan increase the activity of FFA oxidation enzymes, and elevate fat energy utilization. CGA can elevate the expression of PPAR-α mRNA and protein to modulate lipid metabolism. The researchers used green coffee bean extract (GCBE) and CGA for animal experiments, and found that both GCBE and CGA can suppress body weight gain and visceral fat accumulation, and reduce serum cholesterol and fatty acid level. GCBE is helpful for the prevention and treatment of obesity. Key word：green coffee bean extract、Chlorogenic acid、lipid metabolism References Atsushi T, Toshimansa Y, Sato T, Yusuke H, Yusuke I, Toshiyuki M, Takashi K. 2005. Peroxisome proliferator-activated receptor (PPAR)α activation increases adiponectin receptors and reduces obesity-related infl