两种10d序贯疗法与传统三联疗法根除幽门螺杆菌临床效果的比较研究.docVIP

两种10 d序贯疗法与传统三联疗法根除幽门螺杆菌临床效果的比较研究 ：张永强，焦建华，孙谨，王亚 单位：东南大学医学院附属江阴医院东区消化科，江苏江阴 【 】目的:评价含咲喃哇酮和含替硝哇的两种10 d序贯疗法和传统三联疗法根除幽门螺 杆菌(H.pylor)的疗效。方法:将符合入选标准的患者随机分为3组。A组:前5 d沖雷贝拉I坐10 mg+阿莫西林1.0 g,2次middot;d-ljrf 5 cT了雷贝拉哇10 mg+克拉霉索500 mg+咲喃呻酮100 mg,2 次middot;d-lo B 组:前 5 d 予雷贝拉哇 10 mg+阿莫西林 1 000 mg,2 次middot;d-l;后 5 d予雷贝拉醴10 m計克拉霉素500 m計替硝哇500 mg,2次middot;d?l。C组：予雷贝拉 醴10 mg+阿莫西林1 000 mg+克拉霉素500 mg,2次middot;d?l,疗程7 d。记录治疗期间发 生的不良反应。疗程结束停药至少4周以上复查14C UBT(尿素呼气试验)，判断H.pylor 根除情况。结杲:共123例患者纳入研究。按试验方案(PP)分析和意向治疗(ITT)分析,A组根 除率分别为91.43%和84.21 %;B组分别为77.78%和68.29%;C组分别为72.50%和65.91%。 A组与B、C组分别相比较，差异均令统计学意义(均Plt;0.05);B组与C组比较，差异无统计 学意义(Pgt;0.05)。结论:含咲喃呻酮的10 d序贯疗法川于H.pylor感染的初治，疗效明显高 于含替硝喘序贯疗法及7 d三联疗法，可以考虑作为初治患者一线治疗方案的选择之一。 【关键词】螺杆菌，幽门;序贯方案;三联疗法;根除率；咲喃醴酮;替硝醴 Comparative study on two kinds of sequential therapy and the standard triple therapy in Helicobacter pylori infection treatment ZHANG Yong qiang, JIAO Jian hua, SUN Jin, WANG Ya(Department of Gastroenterology, Jiangyin Hospital, Medical College of Southeast University, Jiangyin 214432, China) [Abstract] Objective: To evaluate the eradication rate of H. pylori in furazolidone based sequential therapy, tinidiizole based sequential therapy and 7 day triple regimen. Methods: Patients with pylori positive peptic ulcer disease or chronic gastritis were randomly divided into group A,B and C.Group A received 1() days sequential therapy, i. e., rabeprazole 1() mg plus amoxicillin 1 g for the first 5 days, followed by rabeprazole 10 mg, clarithromycin 500 mg and furazolidone 100 mg for the next 5 days? Group B received rabeprazole 10 mg and amoxicillin lg for the first 5 days, followed by rabeprazole 10 mg, clarithromycin 500 mg and tinidazole 500 mg for the remaining 5 days? Group C received rabeprazole 10 mg,amoxicillin 1 g and clarithromycin 500 mg for 7 days? All drugs were given twice daily. The adverse effects were recorded during the course of treatment. Eradication of H.pylori was determined by 14C urea breath test 4 weeks after completi