家兔高钾血症心电生理机制的研究.DOC

家兔高钾血症心电生理机制的实验研究 姜恒1 刘鸿2 刘伯夫 2 （成都医学院： 1检验医学院输血教研室； 2 基础医学院临床医学系 四川 成都 610083） 【摘要】目的 观察家兔高钾血症心电生理特征，研究家兔高钾血症对心脏的毒性作用机制。方法 先记录家兔正常的心电图特征及血钾浓度，再分别输注l%、4%、10%KCl溶液（2ml/kg）复制高钾血症模型，观察家兔心电生理的变化特征，记录输钾前后血钾浓度、吸光度、心率、心电图异常率及各指标之间的变化关系。结果 实验组输钾前后血钾浓度、吸光度、心率、心电图异常率、心电图各波形时限及振幅差异有显著变化（P0.05），随着输钾浓度增高发生高血钾时间缩短差异具有显著性（P0.05），实验家兔血钾浓度与心电图诊断高血钾症的一致性良好（P0.01），在ROC曲线上心电图变异率诊断水平（P0.01）最高，其次为血钾浓度（P0.05），而心率诊断水平最差（P0.05）,血钾浓度与心电图变异率高度相关（P0.05），血钾浓度与心率相关性较差(P0.05)。结论 实验家兔高血钾症心电生理机制的研究对临床急性高血钾症的鉴别诊断、及时治疗有重要参考价值。 【关键词】高血钾症；家兔；心电生理 中图分类号：R-322；G424.1　　文献标识码: B　　 The experimental study of cardiac electrophysiological mechanisms of hyperkalemia in Rabbit LIU Hong1； JIANG Heng2；LIU Bo-fu1 （1 Department of Clinical Medicine School of Basic Medical; 2 Department of Blood transfusion;Chengdu medical college Chengdu 610083, China) 【Abstract】Objective to study the toxic mechanisms of hyperkalemia on the heart in rabbit,by observing the cardiac electrophysiological characteristics of hyperkalemia in rabbit. Method record the normal ECG characteristics and serum potassium concentration in rabbit, then copy hyperkalemia model by the infusion of l%, 4%, 10% KCl solution (2ml/kg), observe the changes of cardiac electrophysiology characteristics in rabbit, record serum potassium concentration ,absorbance, heart rate, abnormal rate of ECG and the change in the relationship between the various indicators before and after the injection of potassium solution .Result the differences about the serum potassium concentration ,absorbance, heart rate, abnormal rate of ECG, the period and amplitude of ECG waveform , the change in the relationship between the various indicators in the experimental groups were significant variation (P 0.05), the difference about the period shorted of hyperkalemia was significant (P 0.05)with the input potassium concentration increasing , the consistency between serum potassium and ECG diagnosis of hyperkalemia in experimental rabbit was good (P 0.01 ),Th