冠心病患者的血管内皮功能和口服叶酸对其的影响-内科学、心血管病专业论文.docxVIP

冠心病患者血管内皮功能检测及时酸于预研究Changes 冠心病患者血管内皮功能检测及时酸于预研究 Changes ofVascular Endothelial Function and Effect of Oral Folic Acid on沥scular Endothelial Function in the Patients with Coronary Heart Disease Abstract Part I：Evaluate vascular endothelial function in patients with coronary heart disease： OBJECTIVE：To evaluate the vascular endothelial function in the patients with coronary heart disease．(Clad) METHODS：73 patiems undergoing coronary angiography(49 male，24 female，aged 47—77 years old，average 64．75-t-7．98 years)were chosen to this study．According to the result of coronary angiography，the patients were divided into two groups：the CHD group(n=39)and the non。CHD group(n_34)． 1 3 persons who were healthy and withont risk factor of CHD(9 male，4 female，aged 23—45 years old，average 32．5±7．4 years)were also chosen as normal control group．The plasma VⅥ下level was detected using ELISA methods．The endothelial．dependent and independent dilatation of brachial artery were investigated by high frequency linear-array ultrasonography．Then the vascular endothelial function was assessed using these two methods，and the relationship between the vascular endothelial function and the severity of coronary artery stenosis was analysed． RESULTS：(1)The FMD of the CHD group，the non。CHD group and the control group was(4．8 1+2．33)％，(9．294-3．88)％and(1 3．584-1·80)％respectively， 冠心瘸患者血管内皮功能检测及时酸干预研究a 冠心瘸患者血管内皮功能检测及时酸干预研究 a significant difference was obtained among the three groups(p0．05)．The NTG—MD of the three groups were(13．72i3．27)％，(15．64士2．65)％and (1 6．54士2．98)％respectively，no significant difference was shown between the control group and the non-CHD group(p=0．32)，but significant difference was shown between the CHD group and the other two group(p0．05)．the results show that the endothelial·-dependent and——independent vascular dilation of the patients with CHD were damaged，but only endothdiM—dependent vascular dilation was damaged in the non—CHD group．The FMD was inversely correlated with the ba