加味四妙汤对激素性股骨头坏死血液流变学及血清骨钙素影响的实验分析-中医骨伤科学专业论文.docxVIP

加味四妙汤对激素性股骨头坏死血液流变学及血清骨钙素影响的实验研究 加味四妙汤对激素性股骨头坏死血液流变学及血清骨钙素影响的实验研究 摘要 摘要 PAGE PAGE 10 PAGE PAGE 13 Experimental Study on Hemorheology and Serum osteocalcin of Steroid-induced Avascular Necrosis of Femoral Head By Treatment of Jiaweisimiaotang Yangpan(Orthopaedics and Trauma of Traditional Chinese Medicine) Directed by Professor Huang junqing Abstract Objective: This topic uses the Chinese medicine theory as the instruction, to observe four wonderful soup flavored with glucocorticoid -induced avascular necrosis of the rabbit model of blood rheology and serum osteocalcin, study the mechanism of avascular necrosis of the prevention and control of, in order to provide theoretical basis for guiding the clinical application of this drug. Methods: Experiment adopt healthy rabbit 32 for the research object, the random take 8 only to normal control group (normal grou p), the rest of the rabbit as the model group, will build model rats were randomly divided into 3 groups: model control group, model group, 8), four wonderful soup flavored high dose group, high dose group, 8) only four wonderful soup, flavored, low dose g roup, low dose group, 8). Model group gluteus hydrogenated prednisone acetate injection of 7.5 mg/kg, 2 times a week, for 6 weeks, a total of l2. Way to prevent infection and model animals each intramuscular injection of penicillin sodium 50000 u/times, 2 times a week. Normal control group twice a week amount of saline injections. All animals weighing weight, once a week and watch the animals fur, reaction and activity. Building randomly normal group 1 only six weeks, model group 3, only death disease dete ction and imaging examination, confirm early induction of SANFH model. 6 weeks after treatment, pumping the blood examination, all put to death, determination of each group rats hemorrheology indexes and serum osteocalcin, compared and analyzed. Results: 1）Weight measurements: rabbit weight normal group was obviously higher than that of each module of