利尿药和脱水药双语版定稿.pptVIP

第23章 利尿药和脱水药 Diuretics and Dehydrate agents 华中科技大学同济医学院药理学系 授课教师 金满文 Therapeutic Uses acute renal failure? dialysis disequilibrium syndrome acute attacks of glaucoma cerebral edema pre- and postoperatively in ocular surgery 62 Adverse Effects hyponatremia frank pulmonary edema headache, nausea, and vomiting Contraindications anuric with impaired liver function active cranial bleeding (with heart failure or pulmonary congestion ) 63 复习题 1.利尿药的分类及代表药？ 2.比较各类利尿药的作用部位和作用机制？ 3.噻嗪类利尿药的临床应用和不良反应？ 4.呋塞米的不良反应？ 5.螺内酯的不良反应？ 6.甘露醇的临床应用？ Figure 28-5.. NaHCO3 reabsorption in proximal tubule and mechanism of diuretic action of carbonic anhydrase inhibitors. A, antiporter; S, symporter; CH, ion channel. (The actual reaction catalyzed by carbonic anhydrase is OH-?+ CO2→HCO3-; however, H2O →OH-?+ H+, and HCO3-?+ H+?→H2CO3, so the net reaction is H2O + CO2→ H2CO3.) Numbers in parentheses indicate stoichiometry. BL and LM indicate basolateral and luminal membranes, respectively. Figure 28-5.. NaHCO3 reabsorption in proximal tubule and mechanism of diuretic action of carbonic anhydrase inhibitors. A, antiporter; S, symporter; CH, ion channel. (The actual reaction catalyzed by carbonic anhydrase is OH-?+ CO2→ HCO3-; however, H2O→OH-?+ H+, and HCO3-?+ H+→H2CO3, so the net reaction is H2O + CO2→H2CO3.) Numbers in parentheses indicate stoichiometry. BL and LM indicate basolateral and luminal membranes, respectively Figure 28-6. NaCl reabsorption in thick ascending limb and mechanism of diuretic action of Na+-K+-2Cl- symport inhibitors. S, symporter; CH, ion channel. Numbers in parentheses indicate stoichiometry. Designated voltages are the potential differences across the indicated membrane or cell. The mechanisms illustrated here apply to the medullary, cortical, and post macular segments of the thick ascending limb. BL and LM indicate basolateral and luminal membranes, respectively.  GG 11th，2006 Mechanism and Site of Action 24 1.急性肺水肿（Acute pulmonary