基质金属蛋白酶9及其组织抑制物1与子宫内膜异位症的相关性研究-妇产科专业论文.docxVIP

基质金属蛋白酶．9及其组织抑制物．1与子宫内膜异位症的相关性研究 基质金属蛋白酶．9及其组织抑制物．1与子宫内膜异位症的相关性研究 摘要 基质金属蛋白酶．9及其组织抑制物．1与子宫内膜异位症 的相关性研究 摘 要 目的 研究基质金属蛋白酶一9(MMP．9)及其组织抑制物(TIMP．1) 是否与子宫内膜异位症有关。 方法将15例子宫内膜异位症(EMs)轻度、36例重度患者作为实验组 1、2，38例正常者作为对照组。通过ELISA法测定腹水中MMP．9及 TIMP-1值，比较各组两者及其比值的差异。 结果 与对照组比较，EMs轻度组MMP．9、TIMP．1差异均无显著 (p》o．05)， EMs重度组MMP-9、TIMP一1差异有显著性(po．05)； MMP一9／TIMP一1，比较3组均有显著性差异t萨o．05)；EMs轻度、重度相 比较，MMP一9有显著性差异(pO．05)，TIMP-1差异无显著(p加．05)。 结论随着疾病加重，有MMP．9升高、TIMP．1降低、MMP．9／TIMP．1 比值升高，MMP-9、TIMP．1与子宫内膜异位症发生、发展有相关性，特 别是两者的比值，具有重要诊断价值。 关键词：基质金属蛋白酶一9基质金属蛋白酶抑制物一l子宫内膜异 位症 作 者：程维良 指导老师： 陈友国 TheresearchofrelationshipamongMIvlP-9、TIMP-I∞dEadon删nosisThe TheresearchofrelationshipamongMIvlP-9、TIMP-I∞dEadon删nosis The research of relationship among MMP-9、TIMP一1 and Endometriosis Abstract objective To study the relationship among metalloproteinase一9(MMP一9)、 tissue inhibitor ofmetalloproteinase-1(TIMP-1)and Endometriosis． Methods The women with early endometriosis(15 CSSCS)or severe endometriosis(36 cases)and the normals(38 cases)wgwe regarded as observation groups and control group,respectively．Enzyme—labeled Immunosorbent Assay(ELISA)was employed to detect MMP-9 and TIMP-1，and the results were compared within groups． Results The scores of MMP-9 and TIMP-1 did not have significant difference between early endometriosis group and control grouppO．05)； (2)There were significant difference of MMP-9 and T鲫-1 between severe endometriosis group and controt group(pO．05)；The difference of MMP一9／TIMP一1 between three groups was significant po．05)．MMP-9 Was significantly different between early endometriosis group and the severe group(p0．05)，but TIMP wasn’t(p0．05)． Conclusion With the progress of endometriosis，there were advance of MMP一9 and MMP-9，IB4P-1 and loss of T吼fP．1．MMP-9 and TIMP．1 had close relationship with endometriosiS．Especially,the ratios of MMP一9／ TIMP-1 had important diagnostic value． Keywords MMP-9；TIMP-1；Endometriosis Written by： CHENGWei-liang Supervised by： CHEN You-gno Ⅱ 基质金属蛋白酶·9及其组织抑制物-I与子宫内膜异位症