家族性偏头痛辨证分型与CACNA1A基因相关性研究-中西医结合临床专业论文.docxVIP

考虑“肾精不足偏头痛患者有可能更容易发生突变，但由于样本量较小、突变率较 考虑“肾精不足偏头痛患者有可能更容易发生突变，但由于样本量较小、突变率较 低，这一结论尚有待在大样本的研究中证实。 关键词：偏头痛；家族性偏瘫型偏头痛；PCR-SSCP；CACNAl A基因；辨证分型 Study Study on the Re I at i onsh i P between Fam i I i a I M i gra i ne’s D i fferent i at i on of Symptoms and S i gns for C I ass i f i cat i on of Syndrome and Gene CACNAl A SpeciaI ity：Cl inicaI Combinati013 of Ohinese MediOine and Western Medicine Author：Yuqin He Tutor：Prof．Xuanfu Wu Abstract Background：Migraine is a common type of primary headache，which manifests itself as attacks of often severe，throbbing head pain with nausea，vomiting and sensory sensitivity to light and sound．Its etiology is still unclear． However it’S usually thought to be associated with genitics and envierenment． Familial hemiplegic migraine is a rare autosomal dominant migraine with aura． FHM mutations SO far identified include those in CACNAIA，ATPIA2 and SCNIA genes．Among them，CACNAIA gene was best investigated。So far，fifteen different missense mutations have been identified in the CACNAIA gene，related to l 1 different exons．But the association of CACNAIA gene and conmon types of migraine is still unclear．There are many versions about the pathogenesis in tradictional Chinese midicine(TCM)．Generally speaking，it concerns with wind，cold，fire，phiegm，deficiency and stagnant blood．But until now．there isn’t an analysiS specialized in the etiology of familial migraine and it’S differentiation of symptoms and signs for class／fication of syndrome． Objective．I To investigate the fundation of invasion in TCM in familial migraine． and its etiology of molecular genetics． Methods：There were two groups in the part of clinical observation。the observative group contained 20 migraineurs with family history，the control group contained 25 migraineurs without family history．We differentiated symptoms and signs for classification of syndrome according to the patients’ clinical manifestation， and analyzed the different features between distribut