化疗对妇科恶性肿瘤患者绝经症状改变的研究.docVIP

化疗对妇科恶性肿瘤患者绝经症状改变的研究 刘凤玲 (四川省绵阳市三台县人民医院妇产科四川三台621100) 【摘要】目的：研究化疗对妇科恶性肿瘤患者绝经症状改变的影响。方法： 选择2012年1月至2014年5月入住我院治疗的102例妇科恶性肿瘤患者进行研 究。按患者意愿的治疗方式分为观察组与对照组，观察组共82例，对照组共20 例。观察组患者给予紫衫醇联合顺铂静脉滴注化疗，对照组患者实施内分泌治疗、 靶向治疗、手术切除等非化疗方案。结果：观察组患者经化疗后的绝经症状KMI 评分较化疗前升高，患者的绝经症状加重。治疗前两组患者的组间比较无明显差 异(P0.05),两组患者治疗前后的KMI评分组内比较、治疗后的组间对比均存 在显著差异，有可比性和统计学意义(P0.05)；化疗组患者的绝经症状发生率 93.90%,明显高于未化疗组的85.00%,两组间相比差异显著，具有可比性与统 计学意义(U =-2.0406，P=0.0413)o结论：化疗会加重妇科恶性肿瘤患者的绝经 症状，提高患者的绝经症状的评分和绝经症状发生率，直接影响了患者的生活质 量和生命质量。妇科恶性肿瘤患者应慎重选择最佳的治疗方式。 【关键词】化疗；妇科；恶性肿瘤；绝经 【中图分类号1R730.5 【文献标识码】A 【文章编号11004-6194( 2015) 01-0015 - 02 Effects of Chemotherapy on the change of postmenopausal symptoms in patients with gynecologic malignancy 【Abstract】 Objective: To study the influence of Chemotherapy for patients with gynecologic malignancy on postmenopausal symptoms change.Methods: Choose 102 patients with gynecologic malignancy to study from January 2012 to May 2014 to stay in our hospital.According to the difference of the treatment divided into two groups.Gave observation group of 82 cases paclitaxel plus cisplatin infusion chemotherapy, gave 20 cases control group non-chemotherapy treatment.Results： Before treatment between the two groups showed no significant difference between groups (P0.05),there were significant differences in group before and after treatment and between groups, which are comparable and statistically significant (P lt;0.05); incidence of menopausal symptoms in observation group 93.90% is higher than control groupsrsquo; 85.00% ,which were comparable and statistically significant (U = -2.0406, P = 0.0413).Conclusion： Chemotherapy will improve menopausal symptom scores and incidence, which directly affect the quality of life of patients. Gynecological cancer patients should be careful to choose the best treatment. ［Keywords】 chemotherapy; gynecology; malignancies; menopause 在女性肿瘤患者中，卵巢癌、宫颈癌、子宫内膜癌是发病率最高的三大妇科 恶性肿瘤［1］。近年来，妇科恶性肿瘤在我国的发生率呈逐渐上升、年轻化的趋 势，直接威胁着我国女性的生命健康。化疗己成为治疗妇科恶性肿瘤的重要方式, 但在治疗过程中，化疗能有效的杀死肿瘤细胞，也会对