四肢周围神经损伤应用鼠神经生长因子治疗的疗效观察.docVIP

四肢周围神经损伤应用鼠神经生长因子治疗的疗效观 邱红生梁朝莹罗任胡永华韦振飞 (钦州市第一人民医院骨科广丙钦州535000) 【摘要】目的：探讨四肢周围祌经损伤应用鼠祌经生长因子治疗的疗效及 其意义。方法：选择2014年1月至2015年5月在我院住院治疗的四肢周围神经 损伤患者62例，患者用随机数字表分为实验组以及对照组，各31例。实验组患 者选择鼠祌经生长因子联合甲钴胺治疗28天的模式，对照组患者选择用甲钴胺 联合B族维生素治疗28天的模式，评估患者治疗14天及28天的疗效，并观察 药物不良反应。结果：治疗14天及治疗28天实验组患者症状改善率均明显高于 对照组p值分別为0.036、0.020。两组患者在治疗过程中均没有发生严重药物不 良反应事件。实验组患者不良反应与对照组相当p值为0.520。结论：周围神经 损伤患者采用鼠神经生长因子联合甲钴胺治疗的模式的临床效果好于B族维生 素联合甲钴胺治疗的模式，联合用药不增加不良反应，且耐受性较好，值得在临 床上推广。 【关键词】周围神经损伤：鼠神经生长因子：甲钴胺；疗效 【中图分类号】R741 【文献标识码】A 【文章编号】2095-1752 (2016) 17-0074-02 Clinical research of the efficacy analysis on treatment of mouse nerve growth factor injections in patients with peripheral nerve injury QiuHongsheng ,LuoRen,HuYonghua.Department of Orthopedics II, the First Hospital of Qinzhou,Qinzhou Guangxi 535000,China 【Abstract】Objective To investigate the efficacy analysis on I treatment of mouse nerve growth factor injections in patients with peripheral nerve injury .Methods 62 patients of peripheral nerve injury in the First Hospital of Qinzhou in January 2014 to May 2015,whose were divided into two groups according to random number table ,Group experimental, intramuscular injection of mouse nerve growth factor and oral B vitamins tablets 28 day.Group control: intramuscular injection of mecobalamin and oral B vitamins tablets 28 day,Before treatment,at least 14days,28 days,analysis of the test results and observed adverse drug reactions.Results Compared with the control group,symptoms of patients in the experimental group were Significantly alleviated on day 14 after treatment（P=0.036）and on day 28 after treatment （P=0.020）.and side effects fewer.Conclusion Mouse nerve growth factor injections treatment of patients with peripheral nerve injury,there is a good effect to improve their neurological function . 【Key words] Peripheral nerve injury;Mouse nerve growth facto; Mecobalamin tablets;Curative effect 四肢周围神经损伤是骨科临床中常见并发症，有研究表明[1】，骨科临床中 四肢开放性损伤伴有周围神经损伤的发生率为5%，修复后功能完全恢复仅占 10%?25%,治疗和修复周围神经损伤一直是骨科临床研究的焦点。神经生长因 子促进受损