活血补肾法调控慢性盆腔炎模型大鼠抗炎抗氧化及细胞凋亡相关机制的实验研究-中医妇科学专业论文.docxVIP

normal group. The serous levels of MDA in model group were significantly higher than those in normal group（P0.01）；the serous levels of SOD in model group were significantly lower than those in normal group（P0.01）.The uterine tissure expression of Caspase-3， Fas/FasLmRNA and p53mRNA were all significantly increased than those in normal group.After treatment ，the serous levels of pro-inflammatory cytokine（IL-6）in all treatment group were significantly lower than those in model group，meanwhile the anti-inflammatory cytokin（e IL-4）in all treatment group were elevated .The serous levels of MDA in all treatment groupwere significantly decreased than those in model group （P0.01）；the serous levels of SOD in all treatment group were significantly increased than those in model group（P0.01）.The coefficient correlation of the serous levels of SOD and MDA in all Penqiangyan granule groups was 0.798,showing the significant negative correlation（P0.01）. The uterine tissure expression of Caspase-3，Fas/FasLmRNA as well as p53mRNA in all treatment group were significantly increased compared with model group（P0.01）. IL-6、IL-4、SOD and MDA in Penqiangyan granule large dose group were similar to the levels of normal group（P0.05）.Except for IL-6 and Caspase-3 Penqiangyan granule large dose group significantly outweighed the Penyanjing granule group（P0.01）. Except for IL-4 Penqiangyan granule large、 medium dose groups significantly outweighed the Penqiangyan granule small dose group（P0.05）.The coefficient correlation of the uterine tissure expression of FasmRNA and FasLmRNA in all Penqiangyan granule groups was 0.894,showing the significant positive correlation（P0.01）. Conclusions： The method of promoting blood circulation and tonifying the kidney could adjust the levels of the inflammatory cytokines and the corresponding antioxygen indices，thus restore the immune balance effectively so as to inhibit inflammation， speeding up eliminating free radicles，decrease the lipid