活络效灵丹加味对人工关节置换患者术后凝血酶原时间的影响-中医骨伤科学专业论文.docxVIP

活络效灵丹加味对人工关节置换患者术后凝血酶原时间 的影响 中 文 摘 要 目的： 观察活络效灵丹加味对人工关节置换患者术后凝血酶原时 间的影响，探讨该疗法预防人工关节置换术后深静脉血栓形成的科学性 和可行性。 方 法 ：将符合纳入标准的下肢人工关节置换术后 80 例患者按随机 数字表法分为华法林组和中药组各 40 例，中药组术后内服活络效灵丹加 味中药，一日两次，一次 1 袋(100ml)。华法林组术后口服华法林片 2.5mg， 每日 1 次，均治疗 2 周。通过抽血检测两组病例的术前第一天血液凝血 酶原时间(PT)的情况，术后第 7、14、21d 复查血液凝血酶原时间，记录 血液凝血酶原时间。第 28 天两组病例分别用彩色多普勒检查双下肢血管， 统计血栓形成情况。 结果：两组干预前后凝血酶原时间变化情况比较，中药组干预14天， 21天后，凝血酶原时间有延长作用，与华法林组治疗后比较有显著统计 学意义(P＜0.01)。 结论： 活络效灵丹加味对人工关节置换术后患者凝血酶原时间有 延长作用，对预防人工关节置换术后深静脉血栓形成的临床疗效优于华 法林组，而且具有安全、有效、毒副作用小的特点，值得临床推广。 关键词：活络效灵丹,人工关节置换术后,深静脉血栓,凝血酶原时间 The Flavored Huoluoxiao Lingdan replacement surgery affect prothrombin time in patients with artificialjoints ABSTRACT Objective: This paper aims to evaluate the Flavored Huoluoxiao Lingdan’s effect on the patients’ prothrombin time under prosthetic replacement and to discuss this treatment’s scientific basis and viability of preventing the formation of deep venous thrombosis after prosthetic replacement. Methods: Divide 80 patients that qualify the criterion of lower limbs prosthetic replacement equally into two groups, 40 in Warfarin group and 40 in Chinese medicine group. After the operation, patients in Chinese medicine group shall take Flavored Huoluoxiao Lingdan while Warfarin group shall take 2.5mg Warfarin pills. The course of treatment shall last for a fortnight. Results: If compare the time of before and post intervening, the prothrombin time is prolonged after the Chinese medicine group intervened for 7 days, 14 days, and 21 days. This has a remarkable statistical significance comparing to the post-treatment effect of Warfarin group(P＜0.01). Conclusion: Flavored Huoluo Lingdan has a prolonging effect on the prothrombin time of patients under prosthetic replacement. It also has a superior clinical effect on preventing the formation of deep venous thrombosis after prosthetic replacement than the effect of Warfarin group. Also, the treatment of Flavored Huoluoxiao Lingdan is safe, efficacious, and of a less toxic side effect