羟基-喹啉羧酸乙酯的合成及抗球虫活性的研究Studyonthe.PDF

2007 年第 27 卷 有 机 化 学 Vol. 27, 2007 第 8 期, 981～984 Chinese Journal of Organic Chemistry No. 8, 981～984 ·研究论文· 6-芳氧基-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性的研究 邹 燕 a 吴凯群 a 杨祖幸 a 王玉良*,a 侯太平 b 陈淑华 a (a 四川大学化学学院 成都 610064) (b 四川大学生命科学学院 成都 610064) 摘要 设计并合成了 8 个新的 6-芳氧基-4-羟基-3-喹啉羧酸乙酯类化合物. 合成路线短, 产率高, 原料易得, 易实现工 业化. 所有化合物的结构均经 1H NMR, MS, IR 和元素分析所证实. 选择了其中 3 个化合物进行抗球虫活性实验, 结果 表明, 化合物 6-(2- 甲氧苯氧基)-4-羟基-3-喹啉羧酸乙酯具有抗球虫效果, 并有可能作为抗球虫药物使用. 关键词 4-羟基-3-喹啉羧酸乙酯; 合成; 抗球虫活性 Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates ZOU, Yana WU, Kai-Quna YANG, Zu-Xinga WANG, Yu-Liang*,a HOU, Tai-Pingb CHEN, Shu-Huaa (a College of Chemistry, Sichuan University, Chengdu 610064) (b College of Life Science, Sichuan University, Chengdu 610064) Abstract Eight ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process is characterized by short synthetic route, high yield and cheap raw materials, which is con- 1 venient for the commercial production. Structures of the new compounds have been confirmed by H NMR, MS, IR spectra and elemental analysis. Three of the new compounds were chosen for the anticoccidial activ- ity test and the result had shown that ethyl 4-hydroxy-6-(2-methoxypheno