抗神经节苷脂抗体在神经精神狼疮的临床意义-内科学(风湿病)专业毕业论文.docxVIP

抗神经节苷脂抗体在神经精神狼疮的临床意义-内科学(风湿病)专业毕业论文.docx

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万方数据 万方数据 Abstract Objective: Research on anti ganglioside antibodies in patients with nerve spirit erythematosus (NPSLE) in clinical diagnostic significance, seek effective for the diagnosis of patients with basis. Methods: Will be in January 2010 - January 2010, our hospital of 23 patients with systemic lupus erythematosus (SLE) as the study group , including nerve mental erythematosus (NPSLE) 12 cases with the nerve mental lupus (non - NPSLE) 11 cases; In addition to select 10 cases in the same period line health physical examination of normal adults as a control group of this research, the object of this study is analyzed by serum and cerebrospinal fluid. Results: There was significant difference between SLE patients and normal peoples in serum anti-GM1 IgG and IgM level(P0.01);The positive rates of serum anti-GM1 IgG and IgM were both 25.0% in NPSLE,and both 18.2% in no-NPSLE;There was no significant difference between NPSLE and no-NPSLE in serum anti-GM1 level and positive rates(P0.05);There was no significant difference between anti-GM1 IgG and anti- GM1 IgM in serum level and positive rates of NPSLE(P0.05)。The positive rates of CSF anti-GM1 IgG and IgM were both 52.2% in patients with SLE,and both 0.0% in normal peoples;There was significant difference between SLE patients and normal peoples in CSF anti-GM1 antibodies positive rates(P0.01);The positive rates of CSF anti-GM1 IgG were 75.0% in NPSLE,and 27.3% in no-NPSLE;There was significant difference between NPSLE and no-NPSLE in CSF anti-GM1 IgG positive rates (P0.05);The positive rates of CSF anti-GM1 IgM were 83.3% in NPSLE,and 18.2% in no-NPSLE;There was significant difference between NPSLE and no-NPSLE in CSF anti-GM1 IgM positive rates(P0.01);There was no significant difference between anti-GM1 IgG and anti- GM1 IgM in CSF level and positive rates of NPSLE (P0.05)。 Conclusion: CSF anti-GM1 antibodies may be helpful to clinical diagnosis of NPSLE。 Postgraduate student: lan h

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