慢性乙型肝炎患者抗病毒治疗应答及与Th17细胞因子的相关性研究-内科学(传染病)专业毕业论文.docxVIP

第三军医大学硕士学 第三军医大学硕士学位论文 万方数据 万方数据 缩略语表 英文缩写 HBV 英文全称 hepatitis B virus 中文译名 乙型肝炎病毒 HAV HCV hepatitis A virus hepatitis C virus 甲型肝炎病毒 丙型肝炎病毒 EBV CMV HIV CHB ALT AFP PCR VR epstein-Barr virus cytomegalovirus human immunodeficiency virus chronic hepatitis B alanine aminotransferase alpha-fetoprotein polymerase chain reaction virological response EB 病毒 巨细胞病毒 人类免疫缺陷病毒 慢性乙型肝炎 丙氨酸转氨酶 甲胎蛋白 聚合酶链反应 病毒学应答 SR De novo Add-on VB PVR RT LAM serologic response de novo add-on virological breakthrough partial virological response rescue therapy lamivudine 血清学免疫应答 初始联合治疗 添加联合治疗 病毒学突破 部分病毒学应答 挽救治疗 拉米夫定 ADV ETV TDF IFN Peg-IFN RE CTE adefovir entecavir tenofovir interferon pegylated interferon relapse clinical treatment endpoint 阿德福韦酯 恩替卡韦 替诺福韦 干扰素 长效型干扰素 复发 临床治疗终点 SVR ITE Th17 sustained virological response immunologic tolerance T helper 17 持续病毒应答 免疫耐受 T 辅助细胞 17 1 ELISA enzyme-linked immuno sorbent assay 酶联免疫吸附测定 Ep eppendorf 微量离心管 ml milliliter 毫升 μl microliter 微升 CI confidential interval 可信区间 SD/SEM Me standard deviation/mean square error medians 标准差/均方差 中位数 2 Antiviral therapy for chronic hepatitis B patients and correlation studies with T helper cell 17 related cytokines Abstract Hepatitis B virus (HBV) infection is common worldwide (about 350~400 million carriers), and there are 15%-40% population develop into liver cirrhosis, liver failure and hepatocellular carcinoma, these end-stage liver diseases seriously affect the outcome of chronic hepatitis B (CHB) patients. Effective anti-viral therapy can delay or prevent the development of liver diseases. But effective anti-viral therapy is correlated with the type of anti-viral drugs, the time to begin anti-viral therapy, the time to withdraw and host immune reaction. Anti-viral response are divided as follows: virological response; serological response; drug resistance. In recent years, nucleot(s)ide analogs (NUCs) are widely used for its specific anti-viral efficacy, convenience and few side effects. Especially lamivudine (LAM) and