重症肺炎患儿病原菌分布特点及耐药性分析.docVIP

重症肺炎患儿病原菌分布特点及耐药性 分析 王接新 单小鸥 张春霞 叶小君罗越 金佳慧 温州医科大学附属第二医院儿童内分泌科 摘要： 口的探讨和分析重症肺炎患儿病原菌分布特点及抗菌药物耐药趋势。方法选择 2014年1月-2016年12月期间医院收治的218例重症肺炎患儿作为临床研究对 象，并分别对重症肺炎患儿的病原菌分布特点及抗菌药物耐药趋势进行统计分 析。结果218例重症肺炎患儿中共检出病原菌281株，以革兰阴性菌为主，共 147株占52. 31%;以痰液检出为主，共208株占74. 02%;主要革兰阴性菌对阿米 卡星、亚胺培南、头抱哌酮/舒巴坦、美罗培南均表现出较高的耐药性，耐药率 均＞80. 00%,对头抱卩坐林和头抱嚎月亏则均表现出较低的耐药性，耐药率均 〈25.00%。结论 重症肺炎患儿病原菌分布以革兰阴性菌为主，治疗过程中应根据 病原菌的分布特点及耐药趋势科学合理选择抗菌药物。 关键词： 重症肺炎患儿;病原菌分布;抗菌药物;耐药; 收稿日期：2017-08-15 Distribution characteristics of pa/thogens and analysis of drug resistance in children with severe pneumonia WANG Jie-xin SHAN Xiao-ou ZHANG Chun-xia YE Xiao-jun LUO Yue JIN Jia-hui The Second Affiliated Hospital of Wenzhou Medical University; Abstract： OBJECTIVE To probe into and analyze dis trib ution characteris tics and drug resistance trend of pathogens in children with severe pneumonia. METHODS A total of 218 children with severe pneumonia from Jan. 2014 to Dec. 2016 were selected as the cl iniceil subjects. The distribution characteri stics and drug rcsistancc trend of pathogens in children with severe pneumonia were statistically analyzed. RESULTS There were 281 pathogens detected from 218 children with severe pneumonia, which were mainly 147 strains of gram-negative bacteria, accounting for 52. 31%. The main source of pathogens was sputum, which were 208 strains, accounting for 74. 02%. The major gram-negative bactcria showed high rcsistancc to amikacin, imipencm, cefoperazone/sulbactam and meropenem, and the resistant rates were all more than 80%, while had low resistance to cefazolin and cefotaxime, with the resista nt rates lower than 25%. CONCLUSION Pa.t hoge n distrib ution of chiIdren with severe pneumonia is mainly gram-negative bacteria. In the course of trcatment, we should scicntifically and rationally select antibiotics based on the distribution of pathogens and drug resistance trend. Keyword： ChiIdren with severe pneumonia; Distribution of pathogen; Antibacterial drugs; Rcsistancc; Received： 2017-08-15 肺炎属于儿童临床