两亲性壳聚糖衍生物在药物辅料方面的应用研究-应用化学专业论文.docxVIP

乳液。微乳粒子大小均一，形态一致，但比低分子表面活性剂所形成的微乳液粒 乳液。微乳粒子大小均一，形态一致，但比低分子表面活性剂所形成的微乳液粒 子尺寸大得多。由于高分子表面活性剂油溶性差，整个微乳液区均为O，w结构。 微乳体系对葛根素和水飞蓟素的增溶作用大为增加，而对脂溶较强的水飞蓟素的 增溶效果更为突出。 3．微胶囊化前后水飞蓟素和葛根素紫外光谱图类似，最大吸收峰未发生变 化，表明微胶囊化后药物的本质没有发生变化。单凝聚法制得的微囊呈球形颗粒， 复凝聚法制得的微囊形状多为椭圆形。药物微囊化后的体外释放试验表明葛根素 微胶囊化后有较好的缓释效果，且药物释放与介质pH关系不大。 总之，两亲性壳聚糖衍生物可以形成胶束、微乳来增溶乳化疏水难溶药物， 也可以制成微囊来提高药物的稳定性，是很有发展前景的一类新型的药物辅料。 关键词：壳聚糖，药物辅料，胶束，微乳液，微囊 ABSTRACTnle印plication ABSTRACT nle印plication of new ph啪ace嘶cal necessities is very impon日咀t for impr0“ng tlle propenies蛆d bioaVailability of dmgs，hence it is necessary to exploit new pharmaceudcal necessities．Wb aimed to firld a new series of ph眦1aceutical necessities t0 overcome the low solubiIity afld bioaVailability for山e insolubIe dmgs． In tllis paper，me na栅rally occurring poIysacch撕de，chitosan，wIlich has mally uIlique woIlde血l pmpenies，had been umized to syllmesize a ser{es of new type of 锄plliⅢlic cbjtosan pol蛐ric sⅢfactants w11ich删uding(2一hy出oxyl·3-buloxyl) propyl-carboxymetllylch“osall q【BP-cM℃Hs)，(2-hydroxyl-3-dodecano》哆1)propyl- carboxyme廿lyl ctlitosan(HDP-CMCHS)，octane-succinyl—ctlitosaIl(C8一SCCHS)， dacade·succinyl—chitosan(Clo-SCCHS)∞d dodecyl-Succmyl·chitosall(C12·SCCHS)． The s协肥tIlre of me ampllip士lilic deriVatiVes had been a妇丘mled by t11e method of Nuclear Ma印etic Rcsomnce，IR Spec仃oscopy’a11d EIementa工Analysis etc．The 嘶ticaI micdle concenⅡ锄ion of锄p11iphilic chitosall was detectcd by也e nuorescence metllod锄d me micellar systems were characⅫzed by位msmissiOn electron rnjcroscope(TEM)and dyIl锄ic light协g sca仕e血g(DLS)metllods．nle application of pharInaceutical necessities 6N their good solubilization and emlllsifjcation was studied．Puerarin-loaded如d silym撕n-loadcd lnicellar syst锄s Of (2-hydrDxyl一3．butoxyl) propyl- carboxy—metllylcllitosan and (2-hydroxyl-3一 dodecalloxyI)propyl—carboxymetllylcllitosan were characterized by Uv-Vis SpectroscopyTEM a11d DLS me也Ods．The microemulsion of succinyl ch№saIl， heaxene／isoprop锄l／H20 a11d me s01ubilization ai】d emulsmcation南r puer