抗癫痫药物血药浓度监测结果探讨.docVIP

抗癫痫药物血药浓度监测结果探讨 幸勇 宣汉县人民医院四川达州636150 目的探讨抗癫痫药物血药浓度监测特点。方法选取中请监测 抗癫痫药物血药浓度的癫痫患者100例次，均为我院2012年1月至2014年10 月收治，回顾血药浓度监测结果计算血药浓度与不良反应的Eta系数，分析血药 浓度与药物治疗效果的关系。结果抗癫痫药患者100例次中，PT13例次，CB31 例次；PB13例次，VPA43例次；联合用药20例次。依据监测的血药浓度结果， 按A组低于有效浓度、B组在有效范围内、C组高于有效浓度划分，其中A组 40例次，B组56例次，C组4例次。C组VPA、PT、PB、CBZ均高于A组、 B组,有统计学差异(Plt;0.05)联用药20例次，其中PT与其他药物联用5例。 20例次中，监测结果不在药物治疗浓度范围16例，占80%o联用药平均血药 浓度(20.1plusmn;12.8) mu;g/ml,明显高于单用药组(11.0plusmn;8.2) mu;g/mlo A组血药浓度与不良反应的Eta系数为0.558, B组为0.977, C组 为 0.968o A组40例次，总有效率为70%； B组56例次，总有效率为96.4%, C组 4例次，总有效率为50%。木次100例患者中，用药治疗后,A组癫痫再发4次， B组0例，C组3次。结论针对癫痫患者应用抗癫痫药物行血药浓度监测， 可指导临床用药，防范不良反应，提高临床治疗总有效率。 关键词 抗癫痫药物；监测；血药浓度 R742.1 文献标识 码 A 1276-7808 (2015) -06-015-02[Abstract]Objective To investigate the anti epileptic drug blood concentration monitoring features.Methods a total of 100 cases of applicationmonitoring antiepileptic drugs； blood drug concentration in patients with epilepsy were from our hospital in January 2012 to 2014 October.Review of blooddrug concentration monitoring results plasma concentration and adverse reacti on of ETA coefficie nt, analysis the relati on ship between blood drugconcentration and drug treatment efficacy.Results 100 cases of patients with PT13 cases, antiepileptic drugs, CB31 cases； PB13 cases, VPA43 cases； 20 cases of drug combination.According to the monitoring of blood drug concentration results, in group A was lower than that of effective concerttration, B group within the effective range, C group is higher than the effective concentration of division, of which a group of 40 cases, B group (n = 56), groupC (n = 4) .C the VPA group, Pt, Pb, CBZ were significantly higher than those in group A, group B, there are statistical differe nces (P lt; 0.05) combinatio ntherapy in 20 cases, which Pt a nd other drugs combined with 5 cases.Among the 20 cases, the monitoring results in drug concentration range of 16 cases, accounting for 80%.The average drug blood concentration (20.1 + 12.8) g/mb sign讦icantly higher than