急性脑梗死患者纤维蛋白原功能与自由基SOD、MDA的临床研究.docVIP

急性脑梗死患者纤维蛋白原功能与自由基SOD、MDA的临床研究 (1柳州市柳铁中心医院神经内科 广西 柳州54500刀 (2柳州市柳铁中心医院血液科广西柳州54500刀 (3柳州市柳铁屮心医院老年病科广西柳州545007) (4柳州市柳铁中心医院检验科 广西 柳州54500刀 目的：探讨纤维蛋白原功th(fibrinogen function Anticoagulant,Fg)、白由 基SOD和MDA在急性脑梗死发病屮的作用。方法：按CCS评分将100例急性缺 血性脑卒屮病人分为轻型组、屮型组和重型组，并设立对照组100名，分别采用 双抗体夹心ELISA法、黄瞟吟氧化法和比色法动态测定脑梗死组及对照组发病后 或入组后第1天、10天外周血浆Fg和SOD、MDA水平，分析其关系。结果：脑 梗死组各时间点血浆Fg的水平明显高于正常对照组(Plt;0.01)；脑梗死组发病第 1天,SOD水平明显低于对照组，MDA水平明显高于对照组(Plt;0.01),在10天， 两组比较无显著性差异；急性脑梗死患者血浆Fg水平在发病第1、10天随着病 情严重程度而升高，三组比较有显著性差异(Plt;0.01),而SOD和MDA水平只 在发病第1天才与病情严重程度有变化(Plt;0.01)。结论：Fg、MDA和SOD共同 参与脑梗死急性期血管病理损伤过程，Fg可作为评估急性脑梗死患者病情轻重 和预后的客观指标。 关键词 急性脑梗死；纤维蛋白原功能；超过氧化物歧化酶；丙二醛 屮图分类号 R446 A 2095-1752 (2015) 35-0114-02 A Clinical Study on Acute cerebral infarction fibrinogen function and Free Radicals SOD, MDA He jianmingl, Zhu Mingxia2, Xu hong3, Yang dongyi3, Wei Iiumei4 (l.Department of Neurology, 2 .Department of Hematology, 3.Department of Geriatrics, 4.Department of Clinical Laboratory, Liu Liuzhou Railway Central Hospital, Liu Zhu Guang Xil China. 545007) Abstract] Objective To investigate the function of fibrinogen (fibrinogen function Anticoagulant, Fg), Free Radicals SOD and MDA in the role of free radicals in the pathogenesis of acute cerebral infarction.Methods Press CCS score of 100 patients with acute ischemic stroke patients group divided into light, medium group and severe group, and a control group 100, respectively, by double antibody sandwich ELISA method, a xanthine oxidase method and the colorimetric determination of brai n dyn amics in farctio n group and con trol group on day 1, 10 days after the on set of or into the peripheral blood plasma Fg and SOD, MDA level, an a lyze their relati on ships.. Results Fg plasma levels of cerebral in fa ret i on at each time point were sign ifica ntly higher tha n the con trol group (Plt;0.01); the first day of the on set of cerebral infarction group, SOD levels were sigrdficantly lower than the control group, MDA level was sign讦icantly higher (Plt;