急性脑梗死患者颈动脉粥样硬化相关危险因素的研究.docVIP

急性脑梗死患者颈动脉粥样硬化相关危险因素的研究 王伟 张俊清刘波刘洋辛娟娟马天怡（包头医学院第一附属医院神经内一科 014010） 目的探讨急性脑梗死患者颈动脉粥样硬化的相关危险因素，为临 床预防颈动脉粥样硬化提供参考。方法对240例急性脑梗死患者行颈动脉血 管超声检查，根据检查结果分为斑块组和对照组，同时对两组患者的血浆进行 D?D、CysC、甘油三酯、胆固醇、高密度脂蛋白及低密度脂蛋白、空腹血糖、纤 维蛋白原等进行检测，对相关性进行分析。结果斑块组D-D、CysC水平均高 于对照组，差异有统计学意义（P 0.05）；斑块组例数明显多于对照组（P 0.05）,差异有统计学意义；斑块组D?D、CysC呈正相关，且二者均与双侧crouse 积分相关。结论血浆D?D、CysC指标与急性脑梗死患者颈动脉粥样硬化密切 相关，这两个指标可作为预测动脉粥样硬化发牛及程度的因子之一。 关键词 D二聚体；胱抑素C；急性脑梗死；颈动脉粥样硬化 中图分类 号 R2 文献标号 A 2095-7165（ 2015）09-0030-02The investigation of related risk factor of carotid atherosclerosis in patients with acutecerebral infarctionWang Wei, ZhangJunqing, Liu bo, Liu yang, Xin Juanjuan, Ma Tianyi （Department of Neurology, the First Affiliated Hospital of Baotou Medical College, Baotou 014010, China ） Abstract Objective To explore the related risk factors of carotid atherosclerosis in patients with acute cerebral infarction, to provide referenee foratherosclerosis? Methods: Plaques were detected in 240 patients with color doppler ultrasound. According to plaque or not, all the patients weredivided into plaque group and control group. The plasma D-dimer, CysC, total cholestrol, triglyceride, high density lipoprotein, low den sity lipoprotei n,fasti ng plasma glucose, fibrinogen, homocysteine were tested in all patients, to analyse the relationship of atherosclerosis and risk factors? Results Thelevels of D-dimer and CysC in plaque group were significantly higher than those of control group. Plasma D-dimer and CysC were positively correlatedin plaque group. The two indexes were both related with the crouse score. Conclusion: Plasma D-dimer and CysC are closely related to carotidatherosclerosis in patients with acute cerebral infarction, and may be regarded as a predictor of extent of atherosclerosis. Keywords D-dimer； Cystatin C； acute cerebral infarction； carotid atherosclerosis 脑梗死是指各种原因所致脑部血液供应障碍，导致局部脑组织缺血、缺氧性 坏死而出现相应神经功能缺损的一组临床综合征。 其发病率高、复发率高、致残率和死亡率高给社会和家庭带来了沉垂负担, 是当今威胁人类健康和生存的三大主要疾病之一。早期诊断和治疗对于降低其死 亡率、改善预后具有重要意义。颈动脉粥样硬化是一种