探讨与分析麻醉与手术对乳腺癌患者围手术期免疫功能的影响.docVIP

探讨与分析麻醉与手术对乳腺癌患者围手术期免疫功能的 影响 孙燕蒋蓉娟朱波* (四川省成都市第二人民医院 四川 成都610000) 冃的观察与分析不同麻醉方法与手术对乳腺癌患者围手术期细 胞免疫功能的影响。方法选取2012年10月~2014年5月期间收治的50例乳 腺癌手术患者进行研究。随机分为对照组和观察组。对照组采取单纯全麻；观 察组采取全麻联合硬膜外麻醉。两组患者均采用保乳术治疗。观察两组患者术 前、术后CD4+T和CD8+T细胞亚群数量及血清IL?2浓度、镇痛效果。结果术 前，观察组VAS评分为(4.26plusmn;0.52)分与对照组(4.31plusmn;0.47)分比较 (Pgt;0.05)；观察组 VAS 评分为(1.47plusmn;0.29)分与对照组(3.49plusmn;0.35) 分比较(Plt;0.05)。与术前相比较，两组患者术后CD4+T细胞和CD4+/CD8+比值 及血清IL?2浓度均明显下降(Plt;0.05)；但观察组患者CD4+T细胞和IL?2下降程 度无对照组明显，且恢复快(Plt;0.05)o结论对乳腺癌手术患者实施全麻联合 硬膜外麻醉，其具有较好镇痛效果，但其免疫抑制效应明显低于单纯全麻，且术 后恢复快。 关键词 全麻；硬膜外麻醉；乳腺癌；手术；免疫功能 R614 B ]1003-5028 (2015 ) 6-0517-02 [Abstract] Objective: Observation and analysis of different anesthesia methods and surgery perioperative cellular immune function in patients with breast cancer.Methods Selection in June 2012 to May 2014 were study of 50 patients with breast cancer surgery? According to random will be grouped into control group and observation group? Control group: adopt pure general anesthesia;Observation group: take general combined epidural anesthesia? Two groups of patients were treated by modified radical. Observe two groups of patients with preoperative and postoperative CD4 + T and CD8 + T cells subgroup number and concentration of serum IL ? 2 and an algesic effect.Results Before surgery,observation group(4.26plusmn;0.52)for VAS score points compared with the control group (4.31plusmn;0.47) (Pgt;0.05);Observation group (1.47plusmn;0.29) for VAS score points compared with the control group (3.49plusmn;0.35) (Plt;0.05).Compared with the preoperative, two groups of patients with postoperative CD4 + T cells and CD4 + / CD8 + ratio and the concentration of serum IL-2 were significantly decreased (Plt;0.05);But the observation group of patients with CD4+T cells and no control group obviously, IL-2 loss and rapid recovery (P lt; 0.05).Conclusion In patients with breast cancer surgery the implementation of gen eral combi ned epidural an esthesia, it has a good an algesic effect,but its i