自身免疫性疾病英文课件.ppt

HLA-DR3 Myasthenis gravis, SLE HLA-DR4 RA、Type I diabetes HLA-B27 Ankylosing spondylitis 3. Heredity factors Association between HLA allels and diseases Other genes C1q, C4 gene deficiency：SLE DNase deficiency ：SLE mutant CTLA-4：Diabetes Sex IV. Treatment of AID Control infection Administration of immunosuppressive drug Control inflammation Cytokine IL-4→MS Antibodies anti-TNF-α RA anti-CD4 RA anti-MHC II SLE、RA Autoreactive T cell Synovial fibroblast M? IFN-?, IL-17 IL-1, IL-15 IL-1, TNF-? Chondrocyte Osteoclast MMPs, IL-6, IL-8, GM-CSF Cartilage and bone destruction TNF inhibitors IL-1 inhibitor IL-6 inhibitor Oral tolerance T cell vaccine MMPs T cell costimulatory blockers Target Name of therapeutic Product of description Stage of development Current TNF-? Etanercept Soluble p75 TNFR–human IgG1Fc fusion protein Lisenced Infliximab Chimeric mAb specific for TNF-? Lisenced Adalimumab Humanized mAb specific for TNF-α Lisenced IL-1 Anakinra IL-1ra Lisenced IL-6 Tocilizumab Humanized mAb specific for IL-6R Phase III clinical trials In perspective IL-1 AMG 108 Humanized mAb specific for IL-1β Phase II clinical trials IL-15 HuMaxIL-15 (AMG 714) HuMax IL-15 (AMG 714) Phase II clinical trials IL-17 Lubberts E (2008) IL-21 Andersson AK et al (2008) Review questions What are the essential characteristics of AID? Please describe the pathogenic factors related to AID. Autoimmunity and Autoimmune Diseases Autoimmunity is defined as an acquired immune reactivity against self antigens The normal physiological activity essence ----autoimmune response Autoimmune diseases occur when autoimmune responses lead to tissue damage The abnormal physiological activity essence----autoimmune response Breaking of self-tolerance Ehrlich’s “Horror autotoxicus” I. The characteristics and classification of AID 1. The essential characteristics of AID autoantibody，Self-reactive T cells Lead to tissue damage and dysfunction The prognosis is closely related to the intensi