中药加味宁神汤治疗抑郁症的疗效观察.docxVIP

中药加味宁神汤治疗抑郁症的疗效观察 马闯胜高新立闫翌君(河南郑州市第八人民医院450006) 【中图分类号】R277.7 【文献标识码】B 【文章编号】1672-5085 (2010)30-0049-02 【摘要】目的比较中药汤剂加味宁神汤与帕罗西汀治疗抑郁症的疗效和不良 反应。方法将符合研究条件的抑郁症病人随机分成研究组和对照组，分别给予 加味宁神汤和帕罗西汀治疗，研究观察8周，应用汉密尔顿抑郁量表(HAMD) 和副反应量表(TESS)评定疗效和不良反应，分别在治疗前和治疗的2、4、6、 8周末各评定一次。结果 两组治疗后HAMD评分均明显下降(plt;0.01),组间 同期比较无显著差别(pgt;0.05)o研究组有效率为80.95%,与对照组(85.71%) 比较差别无显著意义(x2=0.34,pgt;0.05)o研究组的不良反应发生率为11.90%, 明显低于对照组(30.95%, x2二4.53, plt;0?05)。结论加味宁神汤能有效治疗抑 郁症，疗效与帕罗西汀相当，不良反应更小。 【关键词】 加味宁神汤 帕罗西汀 抑郁症 A comparative study of traditional Chinese medicines in the treatment of depression [Abstract] Objective To study the clin ical effects and side effects of traditional Chinese medicines and paroxetine in thetreatment of depression. Methods 84patients who met the criteria of CCMD-3 for depression were randomly assigned into study group and control group, treated with traditional Chinese medicines and paroxetine for 8 weeks. The clinical effects and side effects were evaluated with Hamilton Depressi on Scale(HAMD) and Treatment Emerge nt Symptom Scale (TESS) before the treatment a nd at thee ndsofthe2 nd、4th、6th、8th week. Results The scores of HAMD of two groups were reduced significantly after treatment (plt;0.01), there were no differenee between two groups at same time (pgt;0.05).The effective rate of study group and control group were 80.95% and 85.71%, there were no sign ifica ntly d iff ere nee (x2=0.34, pgt;0.05). The rate of side effect of study group was 11.90%, it was lower than control group (30.95%, x2=4.53, plt;0.05). Conclusion Traditional Chinese medicines have better effective in the treatment of depression like paroxetine with low side effect. 【Key words] traditional Chinese medicines paroxetine depression. 抑郁症是一种严重影响人们心身健康的精神疾病，以情绪低落、思维迟 缓、动力缺乏等为主要表现，严重者甚至出现厌世自杀，越来越受到社会关注。 其治疗虽然经历了单胺氧化酶抑制剂、传统的三环类抗抑郁剂和新一代抗抑郁剂 等阶段，疗效并未明显提高，不良反应也依然明显。祖国中药治疗抑郁症有着久 远的历史，有报道其疗效与西药相当[1, 2, 3],作者应用中药汤剂加味宁神汤 治疗抑郁症与帕罗西汀作了对照研究，报道如下。 1资料与方法 1.1资料 选取2008年6月至2009年12月在我院住院和门诊治疗的 抑郁症患者为研究对象。入组标准：(1)符合《中国精神障碍分类与诊断标准