多重耐药菌呼吸道感染临床随机对照研究.docxVIP

多重耐药菌呼吸道感染临床随机对照研究 杜蓉 王东 吴友茹 徐维国 陈明勇 王蓉 李惠 (绵阳市中心医院四川绵阳621000) 【摘 要】目的：比较多重耐药菌呼吸道感染不同处理措施的临床效果。方 法：采用随机单盲对照试验，观察组采用非抗生素抗感染治疗措施，对照组采用 抗牛素抗感染治疗措施，疗程7-10 d,分析比较患者临床疗效、影像学改变、痰 培养转阴率、不良反应、治疗费用等方面的差异。结果：共入选病例113例，观 察组54例，对照组59例，两组在临床疗效、痰培养转阴率等方面比较，P值分 别为0.067、0.071,均gt;0.05,差异无统计学意义。在不良反应、药物费用等 方面比较，P值分别为0.042、0.025,均＜0.05,差异有统计学意义。结论：在 多重耐药菌呼吸道感染中使用抗牛素并非有益。 【关键词】多重耐药菌；呼吸道感染；随机对照研究 【中图分类号1R373.1 【文献标识码]B 【文章编号11003-5028(2015) 7-0160-02 Ran domized con trolled clin ical trial for Respiratory tract infectio ns of multi-resista nt bacteria DU Rong, WANG Dong, WU YouRu,, XU WeiGuo, CHEN MingYong, WANG Rong, LI Hui Respiratory medicine , Central Hospital of Mianyang City, Mianyang 621000, China Corresponding author： WU YouRu, Email： durl020@126.com [Abstract 】Objective: To compare the clin ical effects of d iff ere nt treatments in respiratory tract infections by multi-resistant bacteria. Methods: We performed a randomized, single-blinded, controlled clinical trial, observer group: norvantibiotic anti-infective treatment; control group: antibiotics anti-infection treatment; treatment for 7-10 d, analysis of comparative clinical efficacy, radiographic improvement, sputum culture negative rate, conversion rate and cost of treatment d iff ere nces. Results: 113 cases were en rolled, 54 of observer group, 59 of control group; The P values were 0.067、0.071 in the two groups for the clinical efficacy, sputum culture n egative rate. All of them aregt; 0.05, the d if fere nee was not statistically sign讦icant. The P values were 0.042,0.025, for adverse reactions and drug costs, lt;0.05, the d iff ere nee was statistically sign ifica nt. Con clusi on: It is not must be helpful that use of antibiotics in multi-drug resistant respiratory infections. 【Key words] Multidrug resista nt bacteria; Respiratory tract infections; Ran domized con trolled study。 多重耐药菌是指对三种及三种以上抗生素耐药的细菌，常见为医院内感染, 细菌构成以非发酵革兰氏阴性菌、肠杆菌科细菌和金黄色葡萄球菌等多见；其大 多属于条件致病菌，常在免疫力低下、长期住院的患者的呼吸道、尿道及一些植 入体内的开放或半开放性管道内（如尿管、气管插管、深静脉置管