地佐辛与哌替啶治疗急性结石性胆绞痛的疗效与不良反应.docxVIP

地佐辛与哌替噪治疗急性结石性胆绞痛的疗效与不良反应 汤小斌范建华陈鸣 (四川省医学科学院?四川省人民医院药学部成都四川610072) 【摘要】目的比较地佐辛与哌替唳治疗急性结石性胆?绞疼的疗效及不良反 应，为急诊临床用药提供参考。方法釆用地佐辛+阿托品肌肉注射治疗急性结 石性胆绞痛(研究组)，以哌替噪+阿托品治为对照组，观察其疗效及药物不良反 应。结果 研究组与对照组比较，总有效率差异无统计学意义(Pgt;0.05),研 究组疼痛复发率降低，与对照组相比，差异具有统计学意义(Pt;0.05)o恶心 呕吐、眩晕、皮肤瘙痒等药物不良反应研究组明显低于对照组，差异具有统计学 意义(Plt;0.05)。结论 地佐辛肌肉注射对急性结石性胆?绞痛有明显的镇痛作 用，可作为治疗急性结石性胆绞痛的急诊用药。 【关键词】急性结石性胆绞痛地佐辛镇痛哌替噪阿托品 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752 (2014) 02-0154-02 Comparison of Curative Effects and ADRs of Dezocine and Pethidine on Acute Cholecyst Colic of calculi TANG Xiao-bin (Department of Pharmacy, Sichuan Provincial Peoplersquo;s Hospital, Sichuan Academy of Medical Science, Chengdu 610072, China) [ABSTRACT] Objective： To compare the curative effects and ADRs of dezocine and pethidine on acute cholecyst colic of calculi? Methods: The acute cholecyst colic of calculi was therapy by intramuscular injection of dezocine and atropine (test group), mean while pethidine and atropine was used controlled group to observe the curative effects and ADRs. Results: Compared with the control group, the differenee of total effective rate of the test group was no statistical sign讦icant (P gt;0.05), and the relapse rate was significantly lower, the differenee had statistical significant (P lt;O?O5). The adverse drug reactions such as nausea, vomiting, dizziness, skin itching etc. test group was significantly lower than the control group, the differenee was statistically sign讦icant (P lt;0.05). Conclusion: Intramuscular injection of dezocine has good an algesic effect in acute cholecyst colic of calculi and it could be used as the treatment of acute cholecyst colic of calculi in emergency department of hospital. 【KEYWORDS] acute cholecyst colic of calculi dezoci ne an algesia pethidi ne atropi ne 急性结石性胆绞痛是急诊最常见的急腹症之一，它是由于结石在胆囊或胆管 内移动，造成胆囊管或胆总管短时间的梗阻而引起的绞痛。胆绞痛患者通常发病 快，出现右上腹部痛或上腹疼痛，轻重不等，可为间歇性绞痛，也可为持续性疼 痛；如果同吋并发胆道感染，可继发寒战、发热，其至黄疸。我院急诊科采用地 佐辛+解痉药阿托品肌肉注射治疗急性结石性胆绞痛(试验组)，以哌替卩定+解痉 药阿托品为对照组，观察其疗效及药物不良反应。现将结果报道如下。 资料和方法 1.1 一