血管新生-日本炎症再生医学会.PDF

Vol.24 No.5 SEPTEMBER 2004 553 Angiogenesis: Regulation of angiogenesis by hematopoietic cells Blood vessel formation consists of two processes, such as vasculogenesis and angiogenesis. A lot of ligand- receptor system, adhesion molecules, matrix generation and degradation system involves in these processes. Hematopoiesis and blood vessel formation are closely relating, because there are common progenitors termed hemangioblasts those can differentiate into hematopoietic cells and endothelial cells and endothelial cells can support hematopoiesis. Therefore, we have been trying to examine the interaction between hematopoietic cells and endothelial cells especially focusing on the function of hematopoietic cells in promoting angiogen- esis. So far, we found that hematopoietic stem cells promote angiogenesis by producing angiopoietin-1, a ligand for TIE2 expressed on endothelial cells and neuropilin-1 expressed on various lineages of hematopoi- etic cells promotes proliferation of endothelial cells strongly. Moreover, other groups showed that macroph- ages and mast cells produce various kinds of pro-angiogenic cytokine, chemokine, and matrix metalloproteinase and regulate angiogenesis. Those function of hematopoietic cells are utilized physiologic and pathologic situ- ation where angiogenesis is taking place and we recently found that hematopoietic cells regulate tumor angio- genesis very strongly. On the other hand, cell therapy for revascularization in ischemic region have performed using bone marrow cells. There might be contribution of endothelial progenitors for new vessel formation, however, we have to consider that hematopoietic cells in bone marrow regulate angiogenesis in such ischemic region. Rec.7/28/2004,